Cleft Palate

Cleft Palate

Share This Post

What is Cleft Lip or Palate?

A fissure in the midline  of the palate due to the failure of the two sides to fuse in embryonic development. Only part of the palate may be affected, or the cleft may be extend the full length with bilateral clefts at the front of the mouth. The cleft may be accompanied by a split lip and tooth formation disturbances.

Cleft palates can be corrected by surgery.

Research

Mothers of children born with Cleft Lip or Palate were examined for involvement of the MTHFR C677T & A1298C mutation, folic acid supplementation and environmental exposure. Ibarra-Lopez et al (2013) found there to be an increased risk of having a child with C L/P in mothers with C667T or 677TT mutation in comparison to those with the normal C677C genotype. A lack of folate supplementation in the first trimester also contributed to the development of C L/P, which was further compounded by the presence of T677T or C677T MTHFR polymorphism. No association with A1298C in mothers and children with C L/P was found.

Article Here

 

 

Related Posts

Coconut Salmon Zucchini Noodles
MTHFR

Coconut Salmon Zucchini Noodles

Ingredients: Serves 2 2 servings raw zucchini noodles,  2 servings salmon fish  2 Tsp Italian herb mix  1 Tsp dried chili  1 Tsp black pepper ...
Read More →
Histamine Intolerance Histamine intolerance
Genes

HNMT Cofactors and Inhibitors

Histamine Intolerance Histamine intolerance (HIT) is a relatively common condition. The occurrence of HIT is increasing more these days, although the actual mechanism is not ...
Read More →
Vitamin B12 – The ever-important nutrient. What your genetics may tell you?
Genes

Vitamin B12 – The ever-important nutrient. What your genetics may tell you?

One incredibly important nutrient for our every day biochemical function is Vitamin B12. It’s an often overlooked nutrient and I believe many people are deficient ...
Read More →
Blood Clotting
Conditions

Blood Clotting

What Is Blood Clotting? Some people are born with an increased tendency to form blood clots, which increases their risk for developing blood clots in ...
Read More →
Vitamin B6 and MTHFR
MTHFR

Vitamin B6 and MTHFR

The vitamins B12, B6, and folate are vital in developing and maintaining function of the brain. Deficiency in these vitamins at any stage of the ...
Read More →
Orange Pomegranate Salmon
MTHFR

Orange Pomegranate Salmon

Ingredients 1 small red onion, thinly sliced 1 skinned salmon fillet (about 2 pounds) 1/2 teaspoon salt 1 medium navel orange, thinly sliced 1 cup ...
Read More →
Scroll to Top
Carolyn Ledowsky

Stay Connected!

Sign up for our monthly newsletter with current MTHFR research, health tips, recipes, special offers and news about upcoming events including Carolyn’s live Q&A.

Subscribe