Latest Research

As latest research comes to hand, we will post
links and summaries here for you to access.

Is MTHFR Related to Schizophrenia?
Schizophrenia is a serious and devastating mental illness. Contrary to popular belief, the disease is characterized by paranoid delusions, hallucinations,[...]
MTHFR and Fatty Liver
Fatty Liver Disease isn't Just an Alcohol Issue It turns out that alcohol isn't the only culprit when it comes[...]
Folate and Stroke Risk
A stroke can be frightening, debilitating, and sometimes deadly. Strokes are complicated events caused by a variety of contributing factors,[...]
Do MTHFR Mutations Cause Adult Acute Myeloid Leukemia?
Adult acute myeloid leukemia (AML) is a rapidly progressing cancer of the blood and bone marrow that affects the myeloid[...]
Folate and Neural Tube Risk
Zhang et al (2013) have studied the association between several genes involved in folate metabolism and the risk of developing[...]
Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet.
Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into[...]
Maternal Folic Acid Supplementation & Blood Sugar Imbalances
Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into[...]
Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
Methylation Rates with Mutated MTHFR and MTR Genes
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population.
Methylation and the folate pathway are expected to play an important role in the production of health sperm as it[...]
MTHFR and MTRR Mutations & Male Infertility
Methylation and the folate pathway are expected to play an important role in the production of health sperm as it[...]
Increased Resistance to Malaria in Mice with MTHFR Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T Variant
The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for[...]
Does a MTHFR Mutation Increase Resistance to Malaria?
The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease[...]
Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed[...]
MTHFR and Pre-eclampsia
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first[...]
Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
MTHFR & MTR: Differing effects on Methylation
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population
Methylation and the folate pathway are expected to play an important role in the production of health sperm as it[...]
MTHFR and Male Fertility
Methylation and the folate pathway are expected to play an important role in the production of healtyh sperm as they[...]
Increased Resistance to Malaria in Mice with MTHFR Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T Variant.
The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for[...]
Malaria Resistance Due to MTHFR
The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease[...]
Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia.
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed[...]
MTHFR C677T and A1298C with Preeclampsia
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first[...]
Mechanisms Linking In Utero Stress to Altered Offspring Behaviour.
Development while in the uterus is recognised as a determinate of health in later life and is known as early[...]
Stress In Utero + Altered Behaviour in Offspring
Development while in the uterus is recognised as a determinate of health in later life and is known as early[...]
Oxidative Stress, T Cell DNA Methylation and Lupus.
Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as[...]
Lupus, Oxidative Stress and Methylation
Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as[...]
Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women.
African American (EA) women are more likely than European American (EA) women to be diagnosed with breast cancer at a[...]
Folate, B6 and B12 with Breast Cancer Risk
African American (EA) women are more likely than European American (EA) women to be diagnosed with breast cancer at a[...]
Plasma homocysteine levels and genetic polymorphisms in folate metabolism are associated with breast cancer risk in chinese women.
Wu et al (2014) investagted whether genetic mutations of the SHMT, MS, MTRR and CBS genes can affect Homocysteine (Hcy)[...]
Breast Cancer, Methylation Genes and Homocysteine
Wu et al (2014) investigated whether genetic mutations of the SHMT, MS, MTRR and CBS genes can affect Homocysteine (Hcy)[...]
Are Genes Connected with Homocysteine Metabolism Associated with Bipolar Disorder?
High homocysteine levels and mutations in the genes that regulate it have been found in bipolar, depressive and schizophrenic patients.[...]
Bipolar and CBS Pathway Mutation
High homocysteine levels and mutations in the genes that regulate it have been found in bipolar, depressive and schizophrenic patients.[...]
DNA methylation profiling in the thalamus and hippocampus of postnatal malnourished mice, including effects related to long-term potentiation.
Weng et al (2014) conducted research on young mice to examine how extensively DNA methylation within the brain is regulated[...]
Methylation and Its Effects on Brain Function
Weng et al (2014) conducted research on young mice to examine how extensively DNA methylation within the brain is regulated[...]
Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer.
Rai et al (2014) desired to discover the differences in the prevalence of MTHFR C677T and A1298C prevalence in normal[...]
MTHFR and Colon Cancer
Rai et al (2014) wished to discover the differences in MTHFR prevalence in normal and colon cancer tissue. Therefore, DNA[...]
Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection.
Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve[...]
Methylation and HPV/ Cervical Cancer
Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve[...]
Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer.
Song et al (2013) examined the association between cancer related genes (named P16, MGMT and HMLH1) with the prevalence of[...]
Methylation, MTHFR and Gastric Cancer
Song et al (2013) examined the association between several cancer related genes with the prevalence of MTHFR in patients with[...]
Association between methylenetetrahydrofolate reductase C677T polymorphism and epilepsy susceptibility: A meta-analysis.
A meta-analysis on the available evidence concerning the MTHFR C677T polymorphism and susceptibility to epilepsy was studied by Wu et[...]
MTHFR C677T and Epilepsy
A review on the available evidence concerning MTHFR C677T and susceptibility to epilepsy was studied by Wu et al (2014).[...]
Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression
This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age[...]
Folate metabolism and Depression
This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age[...]
Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia
Lochman et al (2014) state a possible epigenetic link between MTHFR C677T mutations, high homocysteine and schizophrenia. 192 schizophrenic patients[...]
MTHHFR C677T and Schizophrenia
Lochman et al (2014) state a possible link between MTHFR C677T mutations, high homocysteine and schizophrenia. Through examining a group[...]
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application
Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that are linked[...]
Folate, Methylation and Depression
Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that have been[...]
Gene Mutations in Cardiovascular Disease
Patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) for the presence of 6 different gene polymorphisms[...]
Homocysteine Level and Mechanisms of Injury in Parkinson’s Disease as Related to MTHFR, MTR, and MTHFD1 Genes Polymorphisms and L-Dopa Treatment
This review article by Rozycka et al (2014) discusses hyperhomocysteinemia (HHcy) and its effect on Alzheimer’s and Parkinson’s Disease. This[...]
High Homocysteine, Parkinson’s and Alzheimer’s Disease
This review article by Rozycka et al (2014) discusses the harmful effects elevated homocysteine (Hcy) levels can play on diseases[...]
MTHFR A1298C & Oesophageal / Gastric Cancer
This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on[...]
A Retrospective Comparative Exploratory Study on two MTHFR Polymorphisms in Esophagogastric Cancer
This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on[...]
MTHFR C677T & High Homocysteine in Vegans
High homocysteine in vegetarians and vegans is mainly related to a deficiency in B12. Therefore, methylation in these people can[...]
C677T Methylenetetrahydrofolate Reductase and Plasma Homocysteine Levels among Thai Vegans and Omnivores
Hyperhomocysteinemia (HHcy) in vegetarians and vegans is mainly related to a deficiency in B12. However, a mutation in the MTHFR[...]
MTHFR C677T & Down’s Syndrome
The presence of the MTHFR C677T mutation was studied in a group of mothers with Down's Syndrome children. Results found[...]
Prevalence of Methylenetetrahydrofolate reductase 677 C-T Polymorphism Among Mothers of Down Syndrome Children
The presence of the MTHFR C677T polymorphism was studied by Kaur (2013) in 110 mothers of children with Down's Syndrome[...]
MTHFR C677T & Coronary Artery Disease
Saffari et al (2013) studied the effect of the MTHFR C677T on high homocysteine levels and therefore coronary artery disease[...]
An MTHFR Variant, Plasma Homocysteine Levels and Late-Onset Coronary Artery Disease in Subjects from Southern Iran
Saffari et al (2013) examined the MTHFR C677T mutation and its potential affect on hyperhomocysteinemia (HHcy) and coronary artery disease[...]
C677T, A1298C, Hypertension & Hypertension in Pregnancy
Yang et al (2014) wished to uncover the role of both the C677T and A1298C mutation in relation to hypertension[...]
Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls
A meta-analysis was conducted by Yang et al (2014) to determine the role of MTHFR polymorphisms in hypertension (H) and[...]
Genetic Variants of Homocysteine Metabolism and Multiple Sclerosis: A case-control study
Ineichen et al (2014) studied the effect the MTHFR A1298C variant had on the development of relapsing remitting multiple sclerosis (RRMS)[...]
Plasminogen Activator Inhibitor-1 4G/5G and the MTHFR 677C/T Polymorphisms and Susceptibility to Polycystic Ovary Syndrome: a meta-analysis.
Lee & Song (2014) conducted a meta-analysis to explore whether plasminogen activator inhibitors-1 (PAI-1) 4G/5G and MTHFR C677T polymorphisms are associated[...]
Adaptive Developmental Plasticity in Methylenetetrahydrofolate reductase (MTHFR) C677T Polymorphism Limits its Frequency in South Indians
This study was completed in order to examine whether the 677TT polymorphism exhibited adaptive developmental plasticity in 1818 South Indian subjects[...]
MTHFR/p53 Polymorphisms as Genetic Factors for Cervical Intraepithelial Neoplasia and Cervical Cancer in HPV-infected Mexican Women
A case control study was undertaken to examine the association between common mTHFR C677T/ A1298C polymorphisms and the Arg72ro polymorphisms in[...]
Genetic Polymorphisms in the Methylenetetrahydrofolate reductase (MTHFR) gene and Risk of Vitiligo in Han Chinese Populations: a Genotype-phenotype Correlation Study
Evidence has recently revealed that patients with vitiligo are shown to have elevated total Homocysteine (Hcy). As MTHFR is one of[...]
MTHFR C677T Polymorphism and Migraine Risk: A meta-analysis.
This meta-analysis was undertaken to review the current evidence available examining the link between the MTHFR C677T polymorphism and migraine risk[...]
Methylenetetrahydrofolate reductase C677T and Overall Survival in Pediatric Acute Lymphoblastic Leukemia: a systematic review.
Ojha and Gurney (2014) conducted a meta-analysis to deduce whether the MTHFR C677T mutation was associated with overall survival in paediatric[...]
Association of ACE and MTHFR Genetic Polymorphisms with Type 2 Diabetes Mellitus:Susceptibility and Complications
Settin et al (2014) researched the link between polymorphisms in both ACE and MTHFR genes and the susceptibility for and complications[...]
Is Methylenetetrahydrofolate reductase (MTHFR) Gene A1298C Polymorphism Related with Varicocele Risk?
The MTHFR enzyme is vital for DNA synthesis and methylation, which has a key role during spermatogenesis. Varicocele is one of[...]
MTHFR C677T Genotype and Cardiovascular Risk in a General Population Without Mandatory Folic Acid Fortification
Studies have suggested an effect of MTHFR C677T genotype on CVD in populations with low dietary folate intake. Therefore, the authors[...]
Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension
The authors Wang et al (2014) studied the ability of the MTHFR C677T polymorphism to predict hyperhomocysteinemia (HHcy) in Chinese patients[...]
Folate: Metabolism, Genes, Polymorphisms and the Associated Diseases.
This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It lists[...]
Polymorphisms of Folate Metabolism-Related Genes and Survival of Patients with Colorectal Cancer in the Korean Population
Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms,[...]
Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase C677T Polymorphism in Cerebral Veno-sinus Thrombosis
The relationship between Homocysteine (Hcy), MTHFR C677T polymorphism and Cerebral Veno-sinus Thrombosis (CVT) in an Indian population was studied by Bharatkumar[...]
Associations Between Methylenetetrahydrofolate reductase Polymorphisms and Hepatocellular Carcinoma Risk in Chinese population.
A meta-analysis conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (HCC) risk in a[...]
Association of Methylenetetrahydrofolate reductase (A1298C and C677T) Polymorphisms with Retinal Vein Occlusion in Tunisian Patients
The link between MTHFR polymorphisms and the aetiology of retinal vein occlusion (RVO) has not been sufficiently clarified. Therefore, 72 Tunisian[...]
Meta-analysis Supports Association of a Functional SNP in the MTHFR Gene with Parkinson’s Disease
A meta-analysis was conducted by Zhu et al (2013) to determine the relationship between the MTHFR C677T polymorphism and the risk[...]
Folic Acid SNP’s Associated with Methotrexate Significant Adverse Events in United States Veterans with Rheumatoid Arthritis
319 patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis were genotyped for several SNP’s involved in the folic acid pathway (folylpoly-gamma-glutamate synthetase[...]
MTHFR & Multiple Sclerosis
The MTHFR enzyme plays a very important role in ensuring the nervous system stays healthy, by governing the coating of[...]
MTHFR C677T & Polycystic Ovarian Syndrome (PCOS)
Lee & Song (2014) conducted research to explore whether MTHFR C677T polymorphisms are associated with susceptibility to Polycystic Ovarian Syndrome[...]
MTHFR C677T Genetic Adaptability
The body has the ability to change its genetics in response to changes in the environment. Therefore, this study was[...]
MTHFR A1298C & Cervical Dysplasia/ Cancer
A case control study was undertaken to examine the association between common MTHFR C677T/ A1298C polymorphisms and the risk for[...]
MTHFR & Vitiligo
Patients with vitiligo are shown to have elevated Homocysteine (Hcy). As MTHFR is one of the main enzymes that regulates[...]
MTHFR C677T & Migraine Risk
This research was undertaken to review the link between the MTHFR C677T and migraine risk. Collective results showed the 677T[...]
MTHFR C677T & Leukaemia Survival
Ojha and Gurney (2014) studied whether MTHFR C677T was associated with overall survival in childhood leukaemia. The current evidence suggests[...]
MTHFR & Type 2 Diabetes Mellitus
Settin et al (2014) researched the link between mutations in the MTHFR genes and the susceptibility for and complications of[...]
MTHFR A1298C & Male Infertility
Varicocele is the presence of widened veins, like varicose veins on the outside of the testicle and is one of[...]
MTHFR C677T + Cardiovascular Risk
Studies have suggested MTHFR C677T plays a role in the development of Cardiovascular Disease (CVD) in populations with low dietary[...]
Predicting High Homocysteine with MTHFR C677T
The authors Wang et al (2014) studied the ability of MTHFR C677T  to predict high homocysteine in Chinese patients with[...]
Review: Folate Metabolism, Genes + Polymorphisms
This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It[...]
MTHFR C677T + Colorectal Cancer
Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic[...]
MTHFR C677T, High Homocysteine + Blood Clot Risk
The relationship between homocysteine (Hcy), MTHFR C677T polymorphism and cerebral (brain) blood clot risk was studied by Bharatkumar et al[...]
MTHFR Polymorphisms & Liver Cancer
Research conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (Liver Cancer) risk in[...]
MTHFR A1298C + C677T Associated with Blood Clotting
The true cause of blood clotting of the retina's vein was examined in this study be Mrad et al (2014).[...]
MTHFR C677T & Parkinson’s Disease Risk
Zhu et al (2013) examined evidence to uncover an association between MTHFR C677T  and the risk of PD, with overall[...]
MTHFR A1298C, Methotrexate & Adverse Events
Research conducted by Davis et al (2014) found patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis had a 3.05 increased risk[...]
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