Latest Research
As latest research comes to hand, we will post
links and summaries here for you to access.
Association between Gut Microbiota and Breast Cancer: Diet as a Potential Modulating Factor
Breast cancer (BCa) has many well-known risk factors, including age, genetics, lifestyle, and diet; however, the influence of the gut[...]
Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review.
This review delves into the intricate relationship between excess folate (vitamin B9) intake, especially its synthetic form, namely, folic acid,[...]
The Role of Magnesium in the Management of Atrial Fibrillation with Rapid Ventricular Rate
"This paper highlights that magnesium glycinate plays a role in helping to regulate the electrical impulses that control the heart’s[...]
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial
"Supplementation of magnesium appears to improve subjective and objective measures of insomnia in elderly people and may become a useful[...]
Fathers’ preconception smoking is associated with a decrease in DNA methylation in the offspring
A paper published recently has shown that fathers' preconception smoking is associated with a decrease in DNA methylation in the[...]
Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review
Background: In preconception and pregnancy, women are encouraged to take folic acid-based supplements over and above food intake. The upper[...]
Recent Literature Finds Strong Link Between COVID-19 & Increased Risk of Neurodegenerative Disorders Such as Alzheimer’s Disease
Study: COVID-19 and risk of Neurodegenerative Disorders: A Mendelian randomization study Article here.
Antioxidant CoQ10 Found to be Effective at Lowering Severity & Duration of Migraines
A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children:[...]
Female Unexplained Infertility: A Disease with Imbalanced Adaptive Immunity
Unexplained infertility (UI) among women consists of only 10-17% of infertile females. Unexplained or idiopathic infertility is a condition, in[...]
The effects of oxidative stress on female reproduction: a review
Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant[...]
Some of the Factors Involved in Male Infertility: A Prospective Review
Infertility is defined as the inability of couples to have a baby after one year of regular unprotected intercourse, affecting[...]
Chronic insomnia in the setting of MTHFR polymorphism
We present a patient with chronic insomnia resistant to traditional pharmacologic (e.g., sedative-hypnotics) and nonpharmacologic (e.g. cognitive behavioral therapy for[...]
Chronic insomnia in the setting of MTHFR polymorphism
We present a patient with chronic insomnia resistant to traditional pharmacologic (e.g., sedative-hypnotics) and nonpharmacologic (e.g. cognitive behavioral therapy for[...]
Association of COMT, BDNF and 5-HTT functional polymorphisms with personality characteristics
The real impact of genetic factors on personality is still unknown, even if in literature about 50% of variance in[...]
N-Acetylcysteine Compared to Metformin, Improves The Expression Profile of Growth Differentiation Factor-9 and Receptor Tyrosine Kinase c-Kit in The Oocytes of Patients with Polycystic Ovarian Syndrome
Background: Paracrine disruption of growth factors in women with polycystic ovarian syndrome (PCOS) results in production of low quality oocyte,[...]
A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder. The long-term use of currently available drugs for the treatment[...]
Topical delivery of l-theanine ameliorates TPA-induced acute skin inflammation via downregulating endothelial PECAM-1 and neutrophil infiltration and activation
l-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral[...]
Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants
Background: Choline needs are increased in pregnancy. Choline can be used as a source of methyl for homocysteine remethylation to[...]
Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial
Background: Probiotics may help to prevent symptoms of anxiety and depression through several putative mechanisms. Objective: The aim of this[...]
A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder. The long-term use of currently available drugs for the treatment[...]
N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Abstract Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. Literature[...]
Obesity, a serious etiologic factor for male subfertility in modern society
Abstract Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder resulting from behavioral, environmental and[...]
Caffeine intake and the risk of first-trimester spontaneous abortion
Abstract Background: Some epidemiologic studies have suggested that the ingestion of caffeine increases the risk of spontaneous abortion, but the[...]
Gut-liver axis at the frontier of host-microbial interactions
Liver and intestine are tightly linked through the venous system of the portal circulation. Consequently, the liver is the primary[...]
The promise of N-acetylcysteine in neuropsychiatry
Abstract N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission,[...]
The role of vitamins in the prevention and control of anaemia
Abstract Objective: While iron deficiency is regarded as the major cause of nutritional anaemia, changes in vitamins A, B12, C[...]
Vitamin D and COVID-19: The Current State of the Evidence
At the beginning of the COVID-19 pandemic, we already knew that vitamin D helps reduce the risk of respiratory infections,[...]
Acute Supplementation with High Dose Vitamin D3 Increases Serum Anti-Müllerian Hormone in Young Women
Anti-Müllerian hormone (AMH) is a paracrine regulator of ovarian follicles. Vitamin D (Vit D) regulates AMH production in vitro, but[...]
Clinical study of Tribulus terrestris Linn. in Oligozoospermia: A double blind study
Infertility is a problem of global proportions, affecting on an average 8-12% of couples worldwide. Low sperm count (Oligozoospermia) is[...]
Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis
Background: Selenium supplementation may decrease circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT), but the available trials are[...]
Rapid recovery from major depression using magnesium treatment
Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where[...]
An Additive Effect of Oral N-Acetyl Cysteine on Eradication of Helicobacter pylori
Abstract Background. Helicobacter pylori is highly adapted to the gastric environment where it lives within or beneath the gastric mucous[...]
The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials
Abstract Taurine plays a pivotal role in regulating glucose and lipid metabolism, blood pressure homeostasis, and obesity largely due to[...]
One in three Americans had COVID-19 by the end of 2020, study estimates
A new study published in the journal Nature estimates that 103 million Americans, or 31 percent of the U.S. population,[...]
‘Feel good’ brain messenger can be willfully controlled, new study reveals
From the thrill of hearing an ice cream truck approaching to the spikes of pleasure while sipping a fine wine,[...]
‘Mycotoxins as potential cause of human infertility’ – Evidence from animal and cell models.
Mycotoxins are toxic metabolites produced by Aspergillus, Penicillium, and Fusarium species of fungi, which can infect and proliferate on various[...]
The Effects of Oxidative Stress On Female Reproduction: A Review
Abstract Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and[...]
The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review
Abstract Human reproduction is not considered a highly efficient biological process. Before the end of the first trimester, 30%-50% of[...]
Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment
Abstract Rationale Anxiety is one of the most comorbid conditions with major depressive disorder (MDD). Depression-associated anxiety often stems from[...]
Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders
Abstract Plant-derived dietary lectins have been reported to be involved in the pathogenesis of several inflammatory diseases, including inflammatory bowel[...]
Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis
Objective We conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement[...]
What fertility specialists should know about the vaginal microbiome: a review
Our understanding of the composition of the microbial communities that inhabit the human body, known as the ‘microbiome’, is aided[...]
Posttraumatic stress disorder is associated with reduced vitamin D levels and functional polymorphisms of the vitamin D binding-protein in a population-based sample
Abstract Objective: Low levels of vitamin D were found to be associated with different mental disorders. However, the role of[...]
Methylenetetrahydrofolate Reductase (MTHFR) genetic polymorphisms and the risk of infertility in couples accessing Assisted Reproductive technologies
Objectives The aim of this literature review is to examine the relationship between Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and assisted reproductive[...]
Higher selenium and manganese levels during pregnancy may protect babies from future high blood pressure
Children who were exposed to higher levels of trace minerals manganese and selenium during their mothers' pregnancy had a lower[...]
Exploring vitamin D metabolism and function in cancer
Vitamin D is a fat-soluble vitamin obtainable from the diet, as well as a seco-steroidal prohormone produced in the skin[...]
Stress can turn hair gray — and it’s reversible, researchers find
Though the legend is inaccurate -- hair that has already grown out of the follicle does not change color --[...]
Dementia Calculator
Dementia is an umbrella term for loss of memory and other thinking abilities severe enough to interfere with daily life.[...]
Posttraumatic stress disorder is associated with reduced vitamin D levels and functional polymorphisms of the vitamin D binding-protein in a population-based sample
Objective: Low levels of vitamin D were found to be associated with different mental disorders. However, the role of vitamin[...]
Calcium Oxalate Crystals in the Thyroid: Their Identification, Prevalence, Origin, and Possible Significance
Calcium oxalate crystals are not encountered in normal animal tissues, except for the human thyroid, where they were found in[...]
The Association between Polymorphisms of Vitamin D Metabolic-Related Genes and Vitamin D3 Supplementation in Type 2 Diabetic Patients
Vitamin D has been found to be involved in a variety of public health-significant diseases including bone diseases [1], diabetes[...]
Vitamin D and Covid-19
Benefits are possible but evidence is sparse, indirect, and inconclusive The covid-19 pandemic has led to many unfounded and exaggerated[...]
Methylenetetrahydrofolate Reductase Gene Polymorphisms in Children with Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is a common childhood neurobehavioural disorder defined by symptoms of developmentally inappropriate inattention, impulsivity and[...]
Long-term endurance training impacts muscle epigenetics
A new study from Karolinska Institute in Sweden shows that long-term endurance training in a stable way alters the epigenetic[...]
Australian Health Survey: Biomedical Results for Nutrients
This publication is the second release of information from the National Health Measures Survey (NHMS), the biomedical component of the[...]
Calcium oxalate crystals in the thyroid. Their identification, prevalence, origin, and possible significance
Calcium oxalate crystals are not encountered in normal animal tissues, except for the human thyroid, where they were found in[...]
Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility
Unexplained infertility (UI), defined as the inability to conceive after 12 months of unprotected intercourse with no diagnosed cause, affects[...]
Experimental drug shows potential against Alzheimer’s disease
Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer's disease in[...]
Among COVID-19 survivors, an increased risk of death, serious illness
As the COVID-19 pandemic has progressed, it has become clear that many survivors -- even those who had mild cases[...]
COVID vaccines and blood clots: five key questions
It has been a difficult week for two COVID-19 vaccines. On 13 April, US regulators urged health-care providers to temporarily[...]
Sugar not so nice for your child’s brain development, study suggests
Sugar practically screams from the shelves of your grocery store, especially those products marketed to kids. Children are the highest[...]
Research shows pain relieving effects of CBD
It's been hailed as a wonder drug and it's certainly creating wonder profits. By some estimates, the Cannabidiol (or CBD)[...]
Among COVID-19 survivors, an increased risk of death, serious illness
As the COVID-19 pandemic has progressed, it has become clear that many survivors -- even those who had mild cases[...]
Choline: Critical Role During Fetal Development and Dietary Requirements in Adults
Choline is an essential nutrient needed for the structural integrity and signaling functions of cell membranes; for normal cholinergic neurotransmission;[...]
Development of a Choline Database to Estimate Australian Population Intakes
The AUSNUT 2011–13 food composition database was expanded to include Australian choline values. The development began with a systematic literature[...]
Choline: Exploring the Growing Science on Its Benefits for Moms and Babies
The importance of ensuring adequate choline intakes during pregnancy is increasingly recognized. Choline is critical for a number of physiological[...]
Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid[...]
The role of GABAA receptors in mediating the effects of alcohol in the central nervous system
Ethanol is a chemically simple compound that produces many well-known effects in humans. The prevailing idea for many years was[...]
GABA and the GABAA receptor
The neurotransmitter gamma-aminobutyric acid (GABA) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.[...]
Can Alcohol Increase Your Risk for Breast Cancer?
Tremendous strides have been made in the treatment and early detection of breast cancer. Even so, over 400,000 people are[...]
Johnson & Johnson Vaccinations Paused After Rare Clotting Cases Emerge
WASHINGTON — Injections of Johnson & Johnson’s coronavirus vaccine came to a sudden halt across the country on Tuesday after[...]
Role of Serotonin and Dopamine System Interactions in the Neurobiology of Impulsive Aggression and its Comorbidity with other Clinical Disorders
Impulsive aggression is characterized by an inability to regulate affect as well as aggressive impulses, and is highly comorbid with[...]
Dopamine and anorexia nervosa
We have suggested that reduced food intake increases the risk for anorexia nervosa by engaging mesolim- bic dopamine neurons, thereby[...]
Novel insights on interactions between folate and lipid metabolism
Folate is an essential B vitamin required for the maintenance of AdoMet-dependent methylation. The liver is responsible for many methylation[...]
Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate
Adequate levels of folates are essential for homeostasis of the organism, prevention of congenital malformations, and the salvage of predisposed[...]
Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements
Periconceptual consumption of folic acid has been shown to decrease the incidence of neural tube defects. The strategy of universal[...]
COVID-19: A methyl-group assault?
The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to ‘long- COVID’ – an increasingly recognized complication of[...]
Molybdenum
Molybdenum, a trace element essential for micro-organisms, plants, and animals, was discovered in 1778 by a Swedish chemist named Karl[...]
Dopamine and serotonin systems modify environmental effects on human behavior: A review
The relative influences of genetic and environmental factors in the development of human behavior have been intensely debated throughout the[...]
How to increase serotonin in the human brain without drugs
For the last 4 decades, the question of how to manipulate the serotonergic system with drugs has been an important[...]
Genetics may free a woman convicted of killing her 4 babies and help other parents explain the unexplainable
Kathleen Folbigg has spent the past 18 years in prison for one of the most horrific crimes imaginable: killing all[...]
NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments
The ongoing pandemic disease named by the World Health Organization (WHO) coronavirus disease 2019 (COVID-19), is caused by Severe Acute[...]
COMBINED EFFECTS OF ELECTROMAGNETIC FIELDS ON IMMUNE AND NERVOUS RESPONSES
COMBINED EFFECTS OF ELECTROMAGNETIC FIELDS ON IMMUNE AND NERVOUS RESPONSES P. BOSCOLO', M. DI GIOACCHINOI, L. DI GIAMPAOLOI, A. ANTONUCCII[...]
INGREDIENT OF THE WEEK: WHAT ARE PEGS?
PEG is short for polyethylene glycol. It will some times be spelled out on labels. However, in most of the[...]
#ChemicalCallout: Polyethylene Glycol Compounds (PEGs)
What Are They? Polyethylene glycol compounds are widespread in household products from skin care and cosmetics, to baby wipes and[...]
Anaphylaxis to the first Covid-19 Vaccine: is PEG the culprit?
Immediate-type life-threatening reactions to vaccines are exceedingly rare; they are reported to occur in 1.3 cases per million doses. 1[...]
Antibody-dependent Enhancement (ADE) and Vaccines
Immune responses to pathogens involve many cells and proteins of the immune system. Early during an infection, these responses are[...]
Fc receptors in antibody-dependent enhancement of viral infections
Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral[...]
Antibody-dependent enhancement of virus infection and disease
In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a[...]
Serotonin the happy hormone – It improves mood and prevents depression
The feeling of happiness, satisfaction and mood stability are signs of stable serotonin levels, a hormone that is also classified[...]
New evidence links specific gut bacteria to depression
Perhaps one of the most compelling, and little understood, areas of gut microbiome science is the strange relationship between gut[...]
Microbes Help Produce Serotonin in Gut
Although serotonin is well known as a brain neurotransmitter, it is estimated that 90 percent of the body's serotonin is[...]
Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder
Background: Physical or psychological adversity in childhood is associated with a higher risk for depression in adulthood, and with persistent[...]
Drink tulsi tea regularly to beat stress
Sipping Tulsi Tea for antioxidants and other nutrients: Colder months are closely associated with lowered immunity which in turn increases[...]
Scientists who express different views on Covid-19 should be heard
When major decisions must be made amid high scientific uncertainty, as is the case with Covid-19, we can’t afford to[...]
The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism
Most reproductive failures originate during the periconceptional period and are influenced by the age and the lifestyle of parents-to-be. We[...]
Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age
Background: For the primary prevention of neural tube defects (NTDs), public health authorities recommend women of childbearing age to take[...]
A prenatal supplement with methylfolate for the treatment and prevention of depression in women trying to conceive and during pregnancy
COVID-19 may negatively affect sperm quality and reduce fertility in men, according to German research. The study of 84 men with[...]
MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series
Purpose To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR)[...]
Safety evaluation of calcium L-methylfolate
Background: Women often seek antidepressant alternatives for major depressive disorder (MDD) in anticipation of or during pregnancy. In this preliminary[...]
Zeolite: Investigation of the Effectiveness and Safety as an Oral Chelating Agent for Heavy Metals. A comparison between different commercially available preparations
This case study was performed to evaluate the effectiveness of clinoptilolite zeolite (“zeolite” herein) as an oral chelating agent for[...]
Removal of zinc, copper and lead by natural zeolite—a comparison of adsorption isotherms
An uptake of zinc (Zn), copper (Cu), and lead (Pb) from aqueous solutions by ion exchange on natural zeolitic tuff[...]
A novel Turkish natural zeolite (clinoptilolite) treated with hydrogen peroxide for Ni 2+ ions removal from aqueous solutions
The removal of Ni(II) from aqueous solution by batch adsorption technique using a novel Turkish zeolite from Akdere region was[...]
Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects
PMID- 26500463 OWN - NLM STAT- MEDLINE DCOM- 20160329 LR - 20201209 IS - 1550-2783 (Print) IS - 1550-2783 (Electronic)[...]
Biological and pathobiological aspects of the glycocalyx of the small intestinal epithelium. A review
The mucosa of the small intestine is com- posed of the muscularis mucosae, the lam- ina propria, and the lamina[...]
Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo
Unique and outstanding physical and chemical properties of zeolite materials make them extremely useful in a variety of applications including[...]
DNA Methylation & Toxins
Identifying agents that have long-term deleterious impact on health but exhibit no immediate toxicity is of prime importance. It is[...]
Significant Impact of the MTHFR Polymorphisms and Haplotypes on Male Infertility Risk
Cosmetics, fragrances, and other personal care products are a possible source of human exposure to potentially endocrine-disrupting chemicals, such as[...]
ROS and female reproduction
In a healthy body, ROS (reactive oxygen species) and antioxidants remain in balance. When the balance is disrupted towards an[...]
Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls- Findings from the HERMOSA Intervention Study
Cosmetics, fragrances, and other personal care products are a possible source of human exposure to potentially endocrine-disrupting chemicals, such as[...]
Physiological aspects of female fertility
The most powerful influence relating to a woman’s chance of conceiving is her age. Female age has physiological and genetic[...]
Mutation Update and Review of Severe Methylenetetrahydrofolate Reductase Deficiency
Methylenetetrahydrofolate reductase (MTHFR; MIM #607093; E.C. 1.5.1.20) is a cytoplasmic enzyme that catalyzes the physio- logically irreversible reduction of 5,10-methylenetetrahydrofolate[...]
Homocystiene and cardiovascular disease
An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomo- cysteinemia, is emerging as a prevalent and strong risk[...]
Folate- Metabolism, genes, polymorphisms and the associated diseases
Folate being an important vitamin of B Complex group in our diet plays an important role not only in the[...]
Circadian Rhythm, Disease Prevention and an Unexpected Liver Gene Linked to our Body Clock
These two articles reinforce the critical importance of proper circadian rhythm for our health and the second article points out[...]
Reducing Muscle Loss
An interesting study that your patients may appreciate focuses on a potential support for muscle loss. It is well established[...]
COVID vaccines and safety: what the research says
It is clear that coronavirus vaccines are safe and effective, but as more are rolled out, researchers are learning about[...]
Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study
Scarce data are available on what variables affect the risk of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),[...]
Exercise and fertility: an update
The last several decades have resulted in a tremendous upsurge in physical activity among both men and women. This enhancement[...]
Determining the Association between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms and Genomic DNA Methylation Level: A Meta-Analysis
Folate deficiency has been linked to many different pathol- ogies, including cancer and birth defects (Czeizel and Dudas, 1992; Bhargava[...]
Choline, homocysteine, and pregnancy
Choline is a dietary component essential for the structural integrity and signaling functions of cell membranes; it directly affects cholinergic[...]
Association between a single nucleotide polymorphism in MTHFR gene and polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine–metabolic disorder, affecting 5–10% of reproductive age women. According to the American[...]
5,10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HUGE Review
The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism. The MTHFR gene is located on chromosome 1 (1p36.3), and[...]
Grounding and How It Helps Your Health
You’ve always been encouraged to let your fingers do the walking. Now is it time to let your feet do[...]
The power of understanding your patient’s genetic susceptibility
Here’s what we know: the increased likelihood of developing a particular disease or condition, such as cancer, obesity, diabetes, heart[...]
Is MTHFR Related to Schizophrenia?
Schizophrenia is a serious and devastating mental illness. Contrary to popular belief, the disease is characterized by paranoid delusions, hallucinations,[...]
MTHFR and Fatty Liver
Fatty Liver Disease isn't Just an Alcohol Issue It turns out that alcohol isn't the only culprit when it comes[...]
Folate and Stroke Risk
A stroke can be frightening, debilitating, and sometimes deadly. Strokes are complicated events caused by a variety of contributing factors,[...]
Do MTHFR Mutations Cause Adult Acute Myeloid Leukemia?
Adult acute myeloid leukemia (AML) is a rapidly progressing cancer of the blood and bone marrow that affects the myeloid[...]
Folate and Neural Tube Risk
Zhang et al (2013) have studied the association between several genes involved in folate metabolism and the risk of developing[...]
Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet.
Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into[...]
Maternal Folic Acid Supplementation & Blood Sugar Imbalances
Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into[...]
Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
Methylation Rates with Mutated MTHFR and MTR Genes
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population.
Methylation and the folate pathway are expected to play an important role in the production of health sperm as it[...]
MTHFR and MTRR Mutations & Male Infertility
Methylation and the folate pathway are expected to play an important role in the production of health sperm as it[...]
Increased Resistance to Malaria in Mice with MTHFR Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T Variant
The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for[...]
Does a MTHFR Mutation Increase Resistance to Malaria?
The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease[...]
Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed[...]
MTHFR and Pre-eclampsia
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first[...]
Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
MTHFR & MTR: Differing effects on Methylation
As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to[...]
Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population
Methylation and the folate pathway are expected to play an important role in the production of health sperm as it[...]
MTHFR and Male Fertility
Methylation and the folate pathway are expected to play an important role in the production of healtyh sperm as they[...]
Increased Resistance to Malaria in Mice with MTHFR Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T Variant.
The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for[...]
Malaria Resistance Due to MTHFR
The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease[...]
Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia.
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed[...]
MTHFR C677T and A1298C with Preeclampsia
Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first[...]
Mechanisms Linking In Utero Stress to Altered Offspring Behaviour.
Development while in the uterus is recognised as a determinate of health in later life and is known as early[...]
Stress In Utero + Altered Behaviour in Offspring
Development while in the uterus is recognised as a determinate of health in later life and is known as early[...]
Oxidative Stress, T Cell DNA Methylation and Lupus.
Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as[...]
Lupus, Oxidative Stress and Methylation
Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as[...]
Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women.
African American (EA) women are more likely than European American (EA) women to be diagnosed with breast cancer at a[...]
Folate, B6 and B12 with Breast Cancer Risk
African American (EA) women are more likely than European American (EA) women to be diagnosed with breast cancer at a[...]
Plasma homocysteine levels and genetic polymorphisms in folate metabolism are associated with breast cancer risk in chinese women.
Wu et al (2014) investagted whether genetic mutations of the SHMT, MS, MTRR and CBS genes can affect Homocysteine (Hcy)[...]
Breast Cancer, Methylation Genes and Homocysteine
Wu et al (2014) investigated whether genetic mutations of the SHMT, MS, MTRR and CBS genes can affect Homocysteine (Hcy)[...]
Are Genes Connected with Homocysteine Metabolism Associated with Bipolar Disorder?
High homocysteine levels and mutations in the genes that regulate it have been found in bipolar, depressive and schizophrenic patients.[...]
Bipolar and CBS Pathway Mutation
High homocysteine levels and mutations in the genes that regulate it have been found in bipolar, depressive and schizophrenic patients.[...]
DNA methylation profiling in the thalamus and hippocampus of postnatal malnourished mice, including effects related to long-term potentiation.
Weng et al (2014) conducted research on young mice to examine how extensively DNA methylation within the brain is regulated[...]
Methylation and Its Effects on Brain Function
Weng et al (2014) conducted research on young mice to examine how extensively DNA methylation within the brain is regulated[...]
Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer.
Rai et al (2014) desired to discover the differences in the prevalence of MTHFR C677T and A1298C prevalence in normal[...]
MTHFR and Colon Cancer
Rai et al (2014) wished to discover the differences in MTHFR prevalence in normal and colon cancer tissue. Therefore, DNA[...]
Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection.
Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve[...]
Methylation and HPV/ Cervical Cancer
Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve[...]
Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer.
Song et al (2013) examined the association between cancer related genes (named P16, MGMT and HMLH1) with the prevalence of[...]
Methylation, MTHFR and Gastric Cancer
Song et al (2013) examined the association between several cancer related genes with the prevalence of MTHFR in patients with[...]
Association between methylenetetrahydrofolate reductase C677T polymorphism and epilepsy susceptibility: A meta-analysis.
A meta-analysis on the available evidence concerning the MTHFR C677T polymorphism and susceptibility to epilepsy was studied by Wu et[...]
MTHFR C677T and Epilepsy
A review on the available evidence concerning MTHFR C677T and susceptibility to epilepsy was studied by Wu et al (2014).[...]
Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression
This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age[...]
Folate metabolism and Depression
This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age[...]
Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia
Lochman et al (2014) state a possible epigenetic link between MTHFR C677T mutations, high homocysteine and schizophrenia. 192 schizophrenic patients[...]
MTHHFR C677T and Schizophrenia
Lochman et al (2014) state a possible link between MTHFR C677T mutations, high homocysteine and schizophrenia. Through examining a group[...]
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application
Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that are linked[...]
Folate, Methylation and Depression
Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that have been[...]
Evaluation of Factor V G1691A, prothrombin G20210A, Factor XIII V34L, MTHFR A1298C, MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD) panel in south-east region of Turkey
4709 Turkish patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) over a period of 3 years[...]
Gene Mutations in Cardiovascular Disease
Patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) for the presence of 6 different gene polymorphisms[...]
Homocysteine Level and Mechanisms of Injury in Parkinson’s Disease as Related to MTHFR, MTR, and MTHFD1 Genes Polymorphisms and L-Dopa Treatment
This review article by Rozycka et al (2014) discusses hyperhomocysteinemia (HHcy) and its effect on Alzheimer’s and Parkinson’s Disease. This[...]
High Homocysteine, Parkinson’s and Alzheimer’s Disease
This review article by Rozycka et al (2014) discusses the harmful effects elevated homocysteine (Hcy) levels can play on diseases[...]
MTHFR A1298C & Oesophageal / Gastric Cancer
This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on[...]
A Retrospective Comparative Exploratory Study on two MTHFR Polymorphisms in Esophagogastric Cancer
This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on[...]
MTHFR C677T & High Homocysteine in Vegans
High homocysteine in vegetarians and vegans is mainly related to a deficiency in B12. Therefore, methylation in these people can[...]
C677T Methylenetetrahydrofolate Reductase and Plasma Homocysteine Levels among Thai Vegans and Omnivores
Hyperhomocysteinemia (HHcy) in vegetarians and vegans is mainly related to a deficiency in B12. However, a mutation in the MTHFR[...]
MTHFR C677T & Down’s Syndrome
The presence of the MTHFR C677T mutation was studied in a group of mothers with Down's Syndrome children. Results found[...]
Prevalence of Methylenetetrahydrofolate reductase 677 C-T Polymorphism Among Mothers of Down Syndrome Children
The presence of the MTHFR C677T polymorphism was studied by Kaur (2013) in 110 mothers of children with Down's Syndrome[...]
MTHFR C677T & Coronary Artery Disease
Saffari et al (2013) studied the effect of the MTHFR C677T on high homocysteine levels and therefore coronary artery disease[...]
An MTHFR Variant, Plasma Homocysteine Levels and Late-Onset Coronary Artery Disease in Subjects from Southern Iran
Saffari et al (2013) examined the MTHFR C677T mutation and its potential affect on hyperhomocysteinemia (HHcy) and coronary artery disease[...]
C677T, A1298C, Hypertension & Hypertension in Pregnancy
Yang et al (2014) wished to uncover the role of both the C677T and A1298C mutation in relation to hypertension[...]
Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls
A meta-analysis was conducted by Yang et al (2014) to determine the role of MTHFR polymorphisms in hypertension (H) and[...]
Genetic Variants of Homocysteine Metabolism and Multiple Sclerosis: A case-control study
Ineichen et al (2014) studied the effect the MTHFR A1298C variant had on the development of relapsing remitting multiple sclerosis (RRMS)[...]
Plasminogen Activator Inhibitor-1 4G/5G and the MTHFR 677C/T Polymorphisms and Susceptibility to Polycystic Ovary Syndrome: a meta-analysis.
Lee & Song (2014) conducted a meta-analysis to explore whether plasminogen activator inhibitors-1 (PAI-1) 4G/5G and MTHFR C677T polymorphisms are associated[...]
Adaptive Developmental Plasticity in Methylenetetrahydrofolate reductase (MTHFR) C677T Polymorphism Limits its Frequency in South Indians
This study was completed in order to examine whether the 677TT polymorphism exhibited adaptive developmental plasticity in 1818 South Indian subjects[...]
MTHFR/p53 Polymorphisms as Genetic Factors for Cervical Intraepithelial Neoplasia and Cervical Cancer in HPV-infected Mexican Women
A case control study was undertaken to examine the association between common mTHFR C677T/ A1298C polymorphisms and the Arg72ro polymorphisms in[...]
Genetic Polymorphisms in the Methylenetetrahydrofolate reductase (MTHFR) gene and Risk of Vitiligo in Han Chinese Populations: a Genotype-phenotype Correlation Study
Evidence has recently revealed that patients with vitiligo are shown to have elevated total Homocysteine (Hcy). As MTHFR is one of[...]
MTHFR C677T Polymorphism and Migraine Risk: A meta-analysis.
This meta-analysis was undertaken to review the current evidence available examining the link between the MTHFR C677T polymorphism and migraine risk[...]
Methylenetetrahydrofolate reductase C677T and Overall Survival in Pediatric Acute Lymphoblastic Leukemia: a systematic review.
Ojha and Gurney (2014) conducted a meta-analysis to deduce whether the MTHFR C677T mutation was associated with overall survival in paediatric[...]
Association of ACE and MTHFR Genetic Polymorphisms with Type 2 Diabetes Mellitus:Susceptibility and Complications
Settin et al (2014) researched the link between polymorphisms in both ACE and MTHFR genes and the susceptibility for and complications[...]
Is Methylenetetrahydrofolate reductase (MTHFR) Gene A1298C Polymorphism Related with Varicocele Risk?
The MTHFR enzyme is vital for DNA synthesis and methylation, which has a key role during spermatogenesis. Varicocele is one of[...]
MTHFR C677T Genotype and Cardiovascular Risk in a General Population Without Mandatory Folic Acid Fortification
Studies have suggested an effect of MTHFR C677T genotype on CVD in populations with low dietary folate intake. Therefore, the authors[...]
Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension
The authors Wang et al (2014) studied the ability of the MTHFR C677T polymorphism to predict hyperhomocysteinemia (HHcy) in Chinese patients[...]
Folate: Metabolism, Genes, Polymorphisms and the Associated Diseases.
This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It lists[...]
Polymorphisms of Folate Metabolism-Related Genes and Survival of Patients with Colorectal Cancer in the Korean Population
Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms,[...]
Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase C677T Polymorphism in Cerebral Veno-sinus Thrombosis
The relationship between Homocysteine (Hcy), MTHFR C677T polymorphism and Cerebral Veno-sinus Thrombosis (CVT) in an Indian population was studied by Bharatkumar[...]
Associations Between Methylenetetrahydrofolate reductase Polymorphisms and Hepatocellular Carcinoma Risk in Chinese population.
A meta-analysis conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (HCC) risk in a[...]
Association of Methylenetetrahydrofolate reductase (A1298C and C677T) Polymorphisms with Retinal Vein Occlusion in Tunisian Patients
The link between MTHFR polymorphisms and the aetiology of retinal vein occlusion (RVO) has not been sufficiently clarified. Therefore, 72 Tunisian[...]
Meta-analysis Supports Association of a Functional SNP in the MTHFR Gene with Parkinson’s Disease
A meta-analysis was conducted by Zhu et al (2013) to determine the relationship between the MTHFR C677T polymorphism and the risk[...]
Folic Acid SNP’s Associated with Methotrexate Significant Adverse Events in United States Veterans with Rheumatoid Arthritis
319 patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis were genotyped for several SNP’s involved in the folic acid pathway (folylpoly-gamma-glutamate synthetase[...]
MTHFR & Multiple Sclerosis
The MTHFR enzyme plays a very important role in ensuring the nervous system stays healthy, by governing the coating of[...]
MTHFR C677T & Polycystic Ovarian Syndrome (PCOS)
Lee & Song (2014) conducted research to explore whether MTHFR C677T polymorphisms are associated with susceptibility to Polycystic Ovarian Syndrome[...]
MTHFR C677T Genetic Adaptability
The body has the ability to change its genetics in response to changes in the environment. Therefore, this study was[...]
MTHFR A1298C & Cervical Dysplasia/ Cancer
A case control study was undertaken to examine the association between common MTHFR C677T/ A1298C polymorphisms and the risk for[...]
MTHFR & Vitiligo
Patients with vitiligo are shown to have elevated Homocysteine (Hcy). As MTHFR is one of the main enzymes that regulates[...]
MTHFR C677T & Migraine Risk
This research was undertaken to review the link between the MTHFR C677T and migraine risk. Collective results showed the 677T[...]
MTHFR C677T & Leukaemia Survival
Ojha and Gurney (2014) studied whether MTHFR C677T was associated with overall survival in childhood leukaemia. The current evidence suggests[...]
MTHFR & Type 2 Diabetes Mellitus
Settin et al (2014) researched the link between mutations in the MTHFR genes and the susceptibility for and complications of[...]
MTHFR A1298C & Male Infertility
Varicocele is the presence of widened veins, like varicose veins on the outside of the testicle and is one of[...]
MTHFR C677T + Cardiovascular Risk
Studies have suggested MTHFR C677T plays a role in the development of Cardiovascular Disease (CVD) in populations with low dietary[...]
Predicting High Homocysteine with MTHFR C677T
The authors Wang et al (2014) studied the ability of MTHFR C677T to predict high homocysteine in Chinese patients with[...]
Review: Folate Metabolism, Genes + Polymorphisms
This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It[...]
MTHFR C677T + Colorectal Cancer
Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic[...]
MTHFR C677T, High Homocysteine + Blood Clot Risk
The relationship between homocysteine (Hcy), MTHFR C677T polymorphism and cerebral (brain) blood clot risk was studied by Bharatkumar et al[...]
MTHFR Polymorphisms & Liver Cancer
Research conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (Liver Cancer) risk in[...]
MTHFR A1298C + C677T Associated with Blood Clotting
The true cause of blood clotting of the retina's vein was examined in this study be Mrad et al (2014).[...]
MTHFR C677T & Parkinson’s Disease Risk
Zhu et al (2013) examined evidence to uncover an association between MTHFR C677T and the risk of PD, with overall[...]
MTHFR A1298C, Methotrexate & Adverse Events
Research conducted by Davis et al (2014) found patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis had a 3.05 increased risk[...]
