MTHFR Support

Latest Research

As latest research comes to hand, we will post links and summaries here for you to access.

Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study

Background Over 48.5 million couples are reported with infertility worldwide. Health policy recommends folic acid in women of childbearing age, particularly in preconception and pregnancy which results in women purchasing over-the-counter prenatal multivitamins containing folic acid through pharmacies and other retail outlets. Emerging studies are investigating whether other forms of

Read More »

Fathers’ preconception smoking and ofspring DNA methylation

A paper published recently has shown that fathers preconception smoking is associated with a decrease in DNA methylation in the offspring. This was associated with asthma in the offspring. This is consistent with research that suggests that disturbances in the epigenome through parental exposures even before the child is conceived

Read More »

Long term folic acid Intake affects estrogen cycle in rats.

A newly published 2024 study concludes that long-term supplemental dose of FA leads to prolongation of Oestrous cycle of Sprague Dawley rats. The study showed that continuous use of folic acid @1mg per day disrupted sex hormones including Luteinising hormone (LH) and Follicle stimulating hormone (FSH) which leads to higher

Read More »

MTHFR affects egg quality and ICSI success.

A brand New 2024 study shows that MTHFR C677T is linked to egg quality. This study out of Iraq looked at the MTHFR C677T polymorphism and its affect on IVF procedures ICSI (intracytoplasmic sperm injection). It included 85 infertile women undergoing ICSI treatment, where they tested oocytes (egg), total embryos,

Read More »

Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review

In preconception and pregnancy, women are encouraged to take folic acid-based supplements over and above food intake. The upper tolerable limit of folic acid is 1000 mcg per day; however, this level was determined to avoid masking a vitamin B12 deficiency and not based on folic acid bioavailability and metabolism.

Read More »
Scroll to Top
Carolyn Ledowsky

Stay Connected!

Sign up for our monthly newsletter with current MTHFR research, health tips, recipes, special offers and news about upcoming events including Carolyn’s live Q&A.