MTHFR Support

Our MTHFR Patient Clinic

Have you considered looking to your genes for answers?

Have you been suffering long term health complaints but can’t seem to get any answers or solutions to fix your symptoms? Are you tired of doctors telling you that everything in your test results are normal, yet you still feel unwell?

Have you considered that your genes may be causing the issue?

Many conditions and diseases are related to genes in some way. Conditions such as fertility issues, anxiety, depression, hormone and thyroid conditions, and even cardiovascular diseases can be caused by issues with multiple genes in combination with diet and lifestyle factors.

Do you want better health for your family?

AT MTHFR Support, we take a holistic, genetics-based look at your health to help patients finally uncover the answers they need to lead better, healthier lives.

Have you considered looking to your genes for answers?

Have you been suffering long term health complaints but can’t seem to get any answers or solutions to fix your symptoms? Are you tired of doctors telling you that everything in your test results are normal, yet you still feel unwell?

Have you considered that your genes may be causing the issue?

Many conditions and diseases are related to genes in some way. Conditions such as fertility issues, anxiety, depression, hormone and thyroid conditions, and even cardiovascular diseases can be caused by issues with multiple genes in combination with diet and lifestyle factors.

Do you want better health for your family?

AT MTHFR Support, we take a holistic, genetics-based look at your health to help patients finally uncover the answers they need to lead better, healthier lives.

Choose your initial package

You will be charged for the plan after the admin approves your vendor account.

Complete Genetic Health Package
Complete Genetic Health Package

Complete Genetic Health Package

AUD $1118

AUD $919

SAVE $200

PAY IN 4 INSTALLMENTS

  • SmartDNA Genetic Test (Valued at
    AUD $440.00 + Shipping + GST if applicable)
  • Initial 1.5 hour practitioner appointment (Valued at AUD $415)
  • 3 month free membership to the Patient Knowledge Centre – this is your one
    stop place for resources, education, downloads for anyone looking for answers to their health issues
  • 10% of all supplements included with your pack and PKC membership saving you
    at least AUD $20 per month
  • Free 15 minute appointment with Elyse our clinic manager to match you with
    your ideal practitioner (Valued at AUD $65)
  • Access to our dedicated Facebook community, to connect with others
    experiencings imilar health concerns
  • Our ‘what is MTHFR’ ebook (Valued at AUD $59)
Complete Fertility Genetic Package
Complete Fertility Genetic Package

Complete Fertility Genetic Package

AUD $1165.8

AUD $959

SAVE $200

PAY IN 4 INSTALLMENTS

  • SmartDNA Genetic Test
    (Valued at AUD $440.00 + Shipping + GST if applicable)
  • Initial 2 hour Appointment with a Fertility Consultant (Valued at AUD $525)
  • 3 month membership to the Fertility Hub – this is your one stop place for resources, education,
    downloads for any one looking for answers for why their fertility is not resulting in a full term
    pregnancy (Valued at AUD $51)*
  • Free 15 minute appointment with Elyse our clinic manager to match you with your ideal practitioner
    (Valued at AUD $65)
  • Access to our dedicated Facebook community, to connect with other couples and share experiences and
    support
  • Our ‘Guide to PreNatals’ eBook – (Valued at AUD $49)

Complete Genetic Health Package

AUD $1118
AUD $ 919
  • smartDNA Genetic Test (Valued at AUD $440.00 + Shipping + GST if applicable)
  • Initial 1.5 hour practitioner appointment (Valued at AUD $415)
  • 3 month free membership to the Patient Knowledge Centre – this is your one stop place for resources, education, downloads for anyone looking for answers to their health issues
  • 10% of all supplements included with your pack and PKC membership saving you at least AUD $20 per month
  • Free 15 minute appointment with Elyse our clinic manager to match you with your ideal practitioner (Valued at AUD $65)
  • Access to our dedicated Facebook community, to connect with others experiencing similar health concerns
  • Our ‘what is MTHFR ebook (Valued at AUD $59)
Save $200

Complete Fertility Genetic Package

AUD $1165.8
AUD $ 959
  • smartDNA Genetic Test (Valued at AUD $440.00 + Shipping + GST if applicable)
  • Initial 2 hour Appointment with a Fertility Consultant (Valued at AUD $525)
  • 3 month membership to the Fertility Hub - this is your one stop place for resources, education, downloads for any one looking for answers for why their fertility is not resulting in a full term pregnancy (Valued at AUD $51)*
  • Free 15 minute appointment with Elyse our clinic manager to match you with your ideal practitioner (Valued at AUD $65)
  • Access to our dedicated Facebook community, to connect with other couples and share experiences and support
  • Our 'Guide to PreNatals' eBook – (Valued at AUD $49)
Save $200

No thanks, I don’t want the special package. I just want to book an initial appointment.

Your genetic susceptibility

You are born with the genes you have. Those cannot change, but you can change the way they act. That means by understanding where your deficiency is, we can support the enzymes with the appropriate nutrients and herbs to help them work better. For example, if the enzyme is too fast, we slow it down. If the enzyme is too slow, we make it work better. By supplying these key pathways with the nutrients they need to work better, you work better.

Your environment also plays a big part. Just because you have a polymorphism, doesn’t mean you have a problem, but the fact that you are here, means that something has triggered a dysfunction. That might be exposure to yeast or mould, virus, gut infections, toxins…. These all have the ability to trigger a pathway upregulation or downregulation, thereby throwing you off kilter. 

Our job is to get you back in your lane and to do this we evaluate your bloods, your biochemistry right now via an organic acids test and we test your genetics. This isn’t testing you for genes like the BRACA gene for breast cancer, but rather your metabolic genes that tells us things like:

  • How well do you detox – can you recycle glutathione?
  • How well do you make methyl folate?
  • Can you use it?
  • What is your ability to make and transport vitamin B12?
  • Are you deficient in any of your brain chemicals that support mood or anxiety?
  • What is your gut likely to be like?
  • Can you make serotonin and melatonin for sleep?
  • Do you have an addictive personality?
  • Are you more prone to anxiety?
  • Are you more prone to depression?
  • Can you get rid of toxic estrogen? Will this affect your weight and hormones?
  • Can you clear histamine well enough? Most people who are allergic, have asthma, eczema and hayfever do not.

These and many more questions are answered by you assessing your metabolic genetics. Its a simple ‘at home’ test that you or any member of your family can do.

Conditions We Support:

Our practitioners are trained to address the following symptoms. Many of our patients have a complicated health history, so whether you have had chronic health issues for a long time, or simply want to prevent yourself and your family going down the same health pathway as your ancestors, we would love to guide you to better health. These are some of the conditions our practitioners focus on:

MTHFR & METHYLATION

We explore your general genetics with a SMART DNA full test + initial appointment

Addictive Behaviours

ADDICTIVE BEHAVIOUR

We explore substance abuse, behavioural, addictions or alcoholism with a Smart DNA + Organic Acids Test + Initial Appointment.

Anxiety & Depression

ANXIETY & DEPRESSION

Understanding your genetic production of key neurotransmitters can help balance your brain chemicals to improve or eliminate your symptoms, leading to life-changing results

Cardiovascular Disease

CARDIOVASCULAR DISEASE

We support cardiovascular diseases (high blood pressure, a family history stroke) with a  Smart DNA + Organic Acids Test + Initial Appointment.

Chemical Sensitivity, Chronic Fatigue & Fibromyalgia

CHEMICAL SENSITIVITY, CHRONIC FATIGUE & FIBROMYALGIA

Address your condition and symptoms with a Smart DNA + Organic Acids Test + Initial Appointment.

Childhood Behaviour

CHILDHOOD BEHAVIOUR

We explore ADD / ADHD / autism / tantrums / learning difficulties with a SMART DNA full test + Organic Acids Test + Initial appointment.

Gut Health & Detox

GUT HEALTH AND DETOX

Get answers to your gut health and detox issues with a GI Map + Organic Acids Test + Initial Appointment.

Hormones

HORMONES & THYROID HEALTH

We explore your hormone and thyroid health with a Dutch Hormone Test + SMART DNA + Initial Appointment.

Infertility & Miscarriage

INFERTILITY & MISCARRIAGE

We explore your fertility with a SMART DNA full test + Organic Acids Test + Dutch Hormone Test + Initial Fertility Appointment.

Long COVID

LONG COVID

We explore your symptoms with a SMART DNA full test + Organic Acids Test + Initial appointment.

Sleep Issues

SLEEP ISSUES

We explore your general genetics with a SMART DNA full test + initial appointment

Trauma Release & Energy healing

TRAUMA RELEASE & ENERGY HEALING

We explore other conditions such as ability to heal + believe past traumas are an obstacle to cure.

Headaches, Migraines, & Allergies

OTHER

We explore other conditions such as cancer support with a Smart DNA + Organic Acids Test + Initial Appointment.

long-term health complaints

Does this sound familiar?

Have you been struggling with long-term health complaints? Have you been unable to get get any answers about your symptoms or how to fix them? Are you frustrated with the constant disregard from your doctors telling you that you are fine and your test results are normal? This is a normal experience for many of our patients.

Your genes may hold the answers you are seeking. Your genes make you unique and each person will have a different make up of gene mutations (also called polymorphisms). Understanding your genetic polymorphisms can help you understand your health better and provide a treatment pathway out of your health problems.

Carolyn Ledowsky

About the patient clinic

Carolyn Ledowsky, founded the MTHFR Support clinic in 2010 in an effort to support patients that were just not getting the answers they needed to improve their health. They were caught in a system that didnt support chronic health care and needed a different way to approach their health.

The MTHFR Support team consists of 9 practitioners, 7 here in Australia and 2 in the United States. This is the largest clinic in the world specifically dedicated to MTHFR polymorphisms and related biochemical genetic susceptibiltiy.

Carolyn believes that understanding YOUR genetic health solution is truly individualised medicine. Is the way of the future. Its who you are.

Carolyn took on the challenge to find solutions for her “difficult” patients. She threw herself into learning all about how your genes can impact your health and how your diet and lifestyle can impact your genes. From here Carolyn has created a dedicated patient clinic specialising in helping people with chronic health issues to heal, utilising their genetic information to improve treatment outcomes; getting results when others have not.

Meet the clinic practitioners

Our practitioners are trained to address the following symptoms. Many of our patients have a complicated health history, so whether you have had chronic health issues for a long time, or simply want to prevent yourself and your family going down the same health pathway as your ancestors, we would love to guide you to better health. These are some of the conditions our practitioners focus on:

RESOURCE:
HISTAMINE MEAL PLAN AND RECIPE BOOK

Webinars

How do your genes affect your detoxification?

DNA Testing and why it might be good for your health

You can stay up to date with the latest research here

Blogs

Alzheimer’s disease
Conditions

Alzheimer’s disease

What is Alzheimer’s Disease? Alzheimer’s Disease is the most common form of dementia, and accounts ...
Read More →
Vitamin B6 and MTHFR
MTHFR

Vitamin B6 and MTHFR

The vitamins B12, B6, and folate are vital in developing and maintaining function of the ...
Read More →
Genes

PODCAST: Interview with Dr Ben Lynch

Last week Carolyn was lucky enough to spend some time interviewing one of the leading ...
Read More →

Clinic FAQs

This acronym stands for Methylene-TetraHydroFolate Reductase. It is an enzyme that converts the folate you eat into the active form that your body needs to use. The 2 main genes involved in this process are MTHFR C677T and A1298C

  • You might have long standing fatigue, and just don’t feel good even though you have had many tests and many doctors/specialists/practitioners have said that there is nothing wrong with you
  • You may have female members of your family that have had a miscarriage or multiple miscarriages, or who have given birth to a child with Neural Tube Defects, cleft lip/palate or Down syndrome
  • You may have oestrogen dominant conditions like: fibrocystic breasts, fibrocystic ovaries, heavy periods, fibroids, endometriosis, terrible PMS
  • You may have family members with issues with their cardiovascular system like high blood pressure, high cholesterol, stroke, heart attack, deep vein thrombosis
  • You may have a family history of depression, anxiety, bipolar
  • You may have allergies, asthma, hives, migraines
  • You or your family members may have been diagnosed with ADD or ADHD
  • You may have had learning difficulties at school / you may find it hard to concentrate
  • You may have issues with inflammation
  • You may have elevated liver enzymes in blood testing
  • You may have elevated red cell folate in blood testing
  • You may have chronic constipation or diarrhoea
  • You may have low B12 levels
  • You may suffer dizziness
  • You may have elevated homocysteine levels
  • You may be on drugs that deplete your B12 and/or folate levels like antacids, cholestyramine, methotrexate, nitrous oxide, high dose niacin, theophylline, Cyclosporin A, metformin, phenytoin, oral contraceptives, antimalarials, antibiotic Trimethoprim, ethanol, Bactrim, sulfasalazine, triamterene.

Methylation is the process by which your body transfers one set of atoms into a series of amino acids, proteins, enzymes and DNA in each and every cell and tissue in your body. The process of methylation is involved with activities such as:

  • Detoxification
  • Repairing and building DNA and RNA
  • Processing hormones
  • Building immune cells
  • Producing energy
  • Repairing cell membranes
  • Turning the stress response on and off
  • Supporting neurotransmitters – the brain’s communication chemicals
  • Supporting fat metabolism

Methyl groups in your body are the ‘on-off’ switches of the cells activities. As your cells are then responsible for all tissues and organs in the body, it is vital they are healthy and working as optimally as possible.

Anything upwards of 45-50% of the general population have some kind of mutation on one of the MTHFR genes.

If you live in Australia, there are 3 main ways to test and discover your MTHFR gene status:

  1. Order and complete an MTHFR Gene Buccal Swab Test Kit via our website.
  2. Via your doctor/ health practitioner & a pathology lab. In this method, you receive a referral for the MTHFR gene test from your doctor or health practitioner (ie. naturopath), and take this form to your closest pathology collection center. The pathologist will take a blood sample for testing, and your results will be sent to your practitioner to share with you. Remember, it is imperative the pathology lab tests for both variants of the MTHFR gene: A1298C and C677T, as receiving results for one mutation will only possibly present 50% of the picture. Note: If you are completing this test through your doctor and you have a family member who is positive for this mutation and/or you have a history of Deep Vein Thrombosis (DVT) or pulmonary embolism, then you may be able to claim the test through Medicare. Please discuss this with your doctor. All tests completed through naturopaths/ nutritionists etc will not be covered by Medicare. However we are happy to give you the referral directly. The cost is approximately $50.
  3. Ancestry DNA – Uncover your ethnic mix, discover distant relatives, and find new details about your unique family history with a simple DNA test. Your DNA raw data is included in your results. Please visit out Resources page.

A positive result means something different for each individual. It is very important to remember that just because you have a mutation does not mean you will necessarily have health issues – known in ‘gene speak’ as expressing. There are many factors that influence genes ranging from stress, to your diet and the environment around you.

If you have chronic disease or you don’t feel well, then it’s likely that various factors have caused an expression of your gene – it is then important for you to seek assistance in understanding your MTHFR mutation and address it.

  • Homozygous: Means you have a copy of the gene mutation from both parents
  • Heterozygous: Means you have one copy of the gene from one parent plus a normal one from the other parent
  • Compound heterozygous: Means you have one copy of the gene mutation and one normal copy for both C677T and A1298C. (You can inherit the copy of the C677T and A1298C gene mutation from the same parent and a normal copy of each from the other parent making the explanation currently showing inaccurate.

The C677T and A1298C mutations cause a down-regulation of the enzyme mentioned above. In the case of the 2 genes this then approximately equates to the following:

  • MTHFR C677T heterozygous = 30-40% loss of function
  • MTHFR C677T homozygous = 60-70% loss of function
  • MTHFR A1298C heterozygous = some % loss of function – Research is NOT clear
  • MTHFR A1298C homozygous = 40% loss of function
  • Compound heterozygous = 40-50% loss of function

Wrong!

In addition to the MTHFR gene, there are a multitude of genes involved in the methylation pathway. Yes, MTHFR is a vitally important gene to start with, but many people can’t cope with methylfolate initially as the body may have issues in other areas and pathways, ie. inflammation, gut health, detoxification or hormonal balance. Introducing methylfolate to the body whilst these issues are still occurring can lead to side effects and/or make your symptoms worse.

It is therefore important to see a professional that knows and understands how to address methylation issues. Some people have no problem with methylfolate, but others have terrible side effects.

If you do begin methylfolate supplementation, below is a list of its related side effects to monitor for:

  • irritability
  • insomnia
  • sore muscles
  • achy joints
  • acne
  • rash
  • severe anxiety
  • palpitations
  • nausea
  • headaches
  • migraines
  • depression
  • suicidal thoughts
Want to know the exact steps you need for a thriving pregnancy?
Join Carolyn’s FREE email Course:
’10 Days to a Healthy Pregnancy with MTHFR’
by clicking here!

 

Any period of rapid growth increases the need for healthy DNA production. Increased demand for the production of healthy DNA is huge during pregnancy due to the intense growth of the foetus.

This DNA production is largely governed by adequate folate levels and therefore, the MTHFR gene.

Impaired methylation is linked with many disease states (e.g. Neural Tube Defects, cardiovascular disease and cancers)

It is thought these diseases result from:

  1. Impaired DNA synthesis and repair
  2. Changes in methylation that negatively change gene expression
  3. If there is a mutated MTHFR gene, the availability of active methyl folate is decreased, then DNA production and gene expression cannot happen as abundantly as required for the growing baby
  4. This is when developmental disorders occur in offspring, such as neural tube defects, congenital heart disease, Down’s Syndrome and cleft lip/palate

Pre-conception and pregnancy have many layers of complexity and consideration, so the information we are able to provide here is limited. For more information on how MTHFR can affect pregnancy, please read the list of blog posts listed below, and consider booking an appointment with one of our experienced team at the clinic to support you T: +61 02 9908 1888 (if calling internationally drop the 0).

MTHFR & Pregnancy/ Preconception articles:

Could MTHFR be the Reason for your Pregnancy Complications?

Why is MTHFR important in preconception and pregnancy?

Top 5 Action Steps for MTHFR in Preconception

 

 

Yes absolutely. The MTHFR team works with many specialists, doctors and other health practitioners around Australia. We have a collaborative approach to health care and believe that your GP and other healthcare practitioners should be across MTHFR and methylation issues.

MTHFR Support Australia has developed a practitioner log in section on this website, enabling your health professional access to detailed information, research, patient handouts and a space to request further information and appointments for patients. We all need to be looking after your health together

You can contact us at:

We will endeavour to reply to all enquiries within a 24-48hr period.

Stay up to date by:

Sign Up for our Patient Portal
Sign Up for our Practitional Portal
Sign Up for our Practitional Portal

Yes. We offer appointments with our expert team at MTHFR Support Australia. We are located at: Suite 216, 40 Yeo Street, Neutral Bay NSW 2089

If you are regional or interstate, please request a Zoom appointment by emailing info@mthfrsupport.com.au or calling + 61 02 9908 1888 (for international callers drop the 0)

As Of April 1, 2019 The Federal Government has stopped the rebate of naturopathy services so rebates will not be available after this date. Some health funds do still rebate Nutrition appointments. Please speak to your Private Health Fund for information.

Our treatment is highly individualised and it is therefore extremely difficult to say. A good way to look at it is, for every year you have a condition allow a month to address it. So if you have been sick for 10 years, it will take 10 months for you to see results. However many of our patients will see results within weeks.

As of early 2016, methylfolate and methylcobalamin have now been cleared for use by the TGA.

MTHFR Support Australia now has its own dedicated products that have been designed specifically for you in mind. Please see our shop page for details.

Most cereal grains contain toxic proteins called prolamines. These are tough proteins that humans can’t digest – we are just not equipped to break down them down into small enough entities to be absorbed. Therefore, these proteins irritate the gut lining and sneak their way past the intestinal wall causing inflammatory and autoimmune reactions. Prolamines include:

  • Gliadin in wheat
  • Zein in corn
  • Avenin in oats

Plant lectins are the other nasty in grains. These toxic, sugar-binding proteins don’t get digested either, and they bind to the cells on the gut wall (enterocytes) and prevent them from completing their normal healing processes (causing them to die).

To understand how going gluten free positively impacts your genetic health, please watch our free webinar recording on Going Gluten Free by clicking here.

The other inflammatory and potentially allergenic food is dairy – especially cow’s milk.

The link to MTHFR – with an MTHFR genetic mutation your body has issues converting and handling certain nutrients – and the harder they are to handle, the more stress it puts on your body. So if you have a positive MTHFR mutation, you have a higher chance of your immune function and detoxification pathways not functioning at 100%.

As such, eliminating gluten and dairy – which as we’ve mentioned, put your body under stress to digest – will help reduce inflammation and the burden on your detox pathways and systems of elimination

  • Low processed food – reduce inflammation and burden on detox pathways and systems of elimination
  • Low alcohol
  • No smoking
  • Maintain a healthy weight
  • High in vegetables – alkalising, natural folate and anti-inflammatory action
  • Modulate stress – uses up methyl groups and cortisol shuts off reproductive function
  • Remove all environmental and household toxins
  • Eat organic where possible
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Carolyn Ledowsky

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