Lee & Song (2014) conducted research to explore whether MTHFR C677T polymorphisms are associated with susceptibility to Polycystic Ovarian Syndrome (PCOS). Analysis of the results showed no correlation between PCOS and the C677T allele. Article Here    

The body has the ability to change its genetics in response to changes in the environment. Therefore, this study was completed by Naushad et al (2014) to examine the 677TT polymorphism and its adaptive ability. Overall, the 677T genotype was associated with 7 fold cumulative risk for Recurrent Pregnancy Loss,

A case control study was undertaken to examine the association between common MTHFR C677T/ A1298C polymorphisms and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in women with the HPV virus. Result suggested that the A1298C polymorphism contributed to the genetic risk for both CIN and

Patients with vitiligo are shown to have elevated Homocysteine (Hcy). As MTHFR is one of the main enzymes that regulates Hcy metabolism, it is hypothesized by authors Chen et al (2014) that mutations to these genes could contribute to vitiligo development. Vitiligo patients showed lower concentrations of MTHFR and therefore

This research was undertaken to review the link between the MTHFR C677T and migraine risk. Collective results showed the 677T allele was significantly associated with an increased risk for total migraine in Asian populations. Article Here    

Ojha and Gurney (2014) studied whether MTHFR C677T was associated with overall survival in childhood leukaemia. The current evidence suggests that individuals with at least one T allele in the C677T gene code may have a decreased risk for leukaemia survival, with the greatest evidence for MTHFR 677TT. Article Here

Settin et al (2014) researched the link between mutations in the MTHFR genes and the susceptibility for and complications of Type 2 Diabetes Mellitus (T2DM). Results showed those with the 677TT and 1298AA mutations were more susceptible to T2DM. Furthermore, these mutations were also found to be risk factors for

Varicocele is the presence of widened veins, like varicose veins on the outside of the testicle and is one of the main reasons for male infertility. The MTHFR enzyme is also vital for production of healthy DNA, which is needed to create healthy sperm. Therefore, Ucar et al (2014) evaluated

Studies have suggested MTHFR C677T plays a role in the development of Cardiovascular Disease (CVD) in populations with low dietary folate intake. Therefore, the authors aimed to examine the association between MTHFR, folate and CVD related outcomes in a population with no mandatory folic acid fortification. Results showed the MTHFR

The authors Wang et al (2014) studied the ability of MTHFR C677T  to predict high homocysteine in Chinese patients with hypertension. Overall, the 677TT genotype was consistently associated with higher homocysteine across the group, with the increase averaging 51%. The authors conclude that the MTHFR C677T polymorphisms could be used

This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It lists the main functional polymorphisms of the MTHFR gene to be C677T and A1298C. In regards to the C677T mutation, the heterozygous C677T mutation functions at 65% activity, with homozygous

Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms, of which MTHFR mutations C677T and A1298C were included. The C677T mutation was the most common MTHFR genotype presentation by the patients in the study, showing predominance toward increased