The relationship between homocysteine (Hcy), MTHFR C677T polymorphism and cerebral (brain) blood clot risk was studied by Bharatkumar et al (2014). Homocysteine was higher in patients with cerebral blood clotting, representing a 4.54 fold increased risk of brain blood clotting. When examining the link with MTHFR C677T, the authors concluded

Research conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (Liver Cancer) risk in a Chinese Population. Results showed that both the C677T and A1298C mutation were significantly associated with an increased susceptibility to liver cancer. Article Here  

The true cause of blood clotting of the retina’s vein was examined in this study be Mrad et al (2014). Results showed the A1298C polymorphism to be significantly associated with clotting of the retinal vein. The C677T gene was found to be significantly higher among these patients. Article Here  

Zhu et al (2013) examined evidence to uncover an association between MTHFR C677T  and the risk of PD, with overall risk found to be increased in European populations compared with Asian populations. Article Here  

Research conducted by Davis et al (2014) found patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis had a 3.05 increased risk of adverse events in the presence of the A1298C mutation. Article Here