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Genetic Variants of Homocysteine Metabolism and Multiple Sclerosis: A case-control study

Ineichen et al (2014) studied the effect the MTHFR A1298C variant had on the development of relapsing remitting multiple sclerosis (RRMS) in a German population. 147 Germans with RRMS matched with 147 healthy controls were screened for their genetic information to be genotypes for 5 polymorphic variants in methionine metabolism. Results showed mutant variants of the CBS and RFC-1 genes may be associated with the age of RRMS onset, with supplementation that affects methionine metabolism a novel idea for preventative and therapeutic strategies.

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