MTHFR Support

Bipolar Disorder

Bipolar Disorder

Share This Post

What is Bipolar?

Bipolar disorder is a severe mental illness causing repeat episodes of depression, mania, or both. These episodes can be precipitated by upsetting events but are out of proportion to the causes.

Bipolar disorder I is the more severe disorder in terms of it’s symptoms – with individuals being more likely to experience more mania, be more likely to have psychotic  episodes and are more likely to be hospitalised.

Bipolar disorder II is diagnosed when a person experiences the symptoms of a high but with no psychotic experiences. These hypomanic episodes tending to last a few hours or a few days.

It is only when these ‘mood-swings’ become extreme and interfere with personal and professional life that bipolar disorder may be present and a psychiatric assessment may be warranted.

Research

1. El-Hadidy et al (2013) aimed to assess the role of the MTHFR C677T mutation in the development of bipolar disorder (BD) and its association with age onset. The presence of the T allele was associated with BD when compared to controls. No correlation between C677T, BD and age of onset was found. Overall, the authors concluded C677T is likely to be associated with the risk of developing BD.

Article Here 

2.High homocysteine levels and mutations in the genes that regulate it have been found in bipolar, depressive and schizophrenic patients. Therefore, Permoda-Osip et al (2014) wished to understand the correlation between bipolar mood disorder and mutations in genes that encode MTHFR, CBS, MTR and MTRR enzymes. Bipolar patients were screened for the presence of these mutations and results compared with a control group. Overall, a gene mutation in the CBS pathway was found to be associated with bipolar, the first evidence of its kind to do.

Related Posts

Grilled Asparagus with Warm Tomato Dressing
MTHFR

Grilled Asparagus with Warm Tomato Dressing

Ingredients: 1 medium tomato (150g) finely chopped (leave out if allergic) 1 clove of garlic, crushed 2 Tbsp fresh lemon juice 1 Tbsp finely chopped ...
Read More →
How to best understand your genetics
Genes

How to best understand your genetics

Genetics is about studying how the genes are passed down from parents to their children. These genes are not only responsible for expressing specific traits ...
Read More →
Clinic Practitioners

Unravelling the Genetic Threads of Diabetes: How Nature, Nurture, and Pregnancy Shape the Future

Introduction: Diabetes, a condition characterised by elevated blood sugar levels, is a complex interplay between genetic susceptibility and environmental influences. Understanding the intricate dance between ...
Read More →
Grass-Fed Beef Liver Pate
MTHFR

Grass-Fed Beef Liver Pate

Ingredients: 453 g grass-fed beef liver (or pasture-raised chicken liver) 1 Tbsp arrowroot powder 4 Tbsp ½ stick butter (from grass-fed cows) 1 medium onion, sliced ½ tsp salt ½ tsp dried thyme pinch of black ...
Read More →
Could MTHFR be the Reason for your Pregnancy Complications?
MTHFR

Could MTHFR be the Reason for your Pregnancy Complications?

While the list of disorders associated with MTHFR mutations can be a long and eye-opening one, those conditions involving pregnancy or the ability to fall ...
Read More →
Wine-Braised Beef Cheeks
MTHFR

Wine-Braised Beef Cheeks

Ingredients: Serves 6 1 kg / 2.2 lbs beef cheeks or chuck trimmed and cut into large chunks 4 onions, sliced 4 large cloves garlic, ...
Read More →
Scroll to Top
Carolyn Ledowsky

Stay Connected!

Sign up for our monthly newsletter with current MTHFR research, health tips, recipes, special offers and news about upcoming events including Carolyn’s live Q&A.

Subscribe