Folate and Brain Is 5-MTHF (methylfolate) better for the brain than folic acid? Methylenetetrahydrofolate reductase (MTHFR) is required for the formation of 5-MTHF in the body, and thus MTHFR deficiency reduces the distribution of folate and the balance between folate for nucleotide synthesis as well as methionine synthesis.[i] The consequences are an increase in homocysteine …
The MTHFR gene is responsible for the production of its enzyme MTHFR, which stands for methylenetetrahydrofolate reductase. The MTHFR enzyme converts folate, in the presence of cofactors, into the active form, 5-methyltetrahydrofolate, for it to be metabolized and used in various biochemical reactions within the human body. This is done through a process called methylation, …
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