NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments
The ongoing pandemic disease named by the World Health Organization (WHO) coronavirus disease 2019 (COVID-19), is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the seventh confirmed RNA single strand beta coronavirus infecting the human beings. According to the WHO, to date (November, 10th 2020), SARS-CoV-2 has affected 50,459,886 people and caused 1,257,523 deaths in the world.
Around 80% of people affected by SARS-CoV-2 infection is asymptomatic or present mild to moderate symptoms, mostly restricted to the upper and conducting airways, often including anosmia and ageusia. The other 20% develops a more critical clinical situation needing hospitalization, which progress, in 5% of cases, in a severe respiratory syndrome requiring ventilatory support and even death (Domingo et al., 2020).