Association between methylenetetrahydrofolate reductase C677T polymorphism and epilepsy susceptibility: A meta-analysis.
A meta-analysis on the available evidence concerning the MTHFR C677T polymorphism and susceptibility to epilepsy was studied by Wu et al (2014). Ten studies totaling 1713 cases and 1867 controls were examined, with a significant association between the C677T mutation and epilepsy susceptibility demonstrated. When analysing the evidence in relation to ethnicity, the results also indicated the MTHFR C677T mutation increased the risk of epilepsy in Asian populations. The authors state further studies are needed in more regions of the world to uncover more evidence on this disease state.