Cardiovascular Disease

Cardiovascular Disease

Share This Post

What Is Cardiovascular Disease?

Heart disease, such as coronary heart disease, heart attack, congestive heart failure, and congenital heart disease, is the leading cause of death for men and women in the U.S. Cardiovascular Disease also encompasses high cholesterol, high triglycerides and hypertension. Prevention includes quitting smoking, lowering cholesterol, controlling high blood pressure, maintaining a healthy weight, and exercising.

Source: Here

Research

1. CVD & Low Folate Intake

Studies have suggested MTHFR C677T plays a role in the development of Cardiovascular Disease (CVD) in populations with low dietary folate intake. Therefore, the authors aimed to examine the association between MTHFR, folate and CVD related outcomes in a population with no mandatory folic acid fortification.

Results showed the MTHFR genotype was not associated with hypertension, dyslipidaemia, stroke or all-cause mortality. Those with the MTHFR 677TT genotype were found to have a higher risk of Ischemic Heart Disease.

Article Here

2. High Homocystiene with Hypertension

The authors Wang et al (2014) studied the ability of MTHFR C677T  to predict high homocysteine in Chinese patients with hypertension. Overall, the 677TT genotype was consistently associated with higher homocysteine across the group, with the increase averaging 51%. The authors conclude that the MTHFR C677T polymorphisms could be used  screening marker for severely high homocysteine.

Article Here

3. MTHFR C677T & Coronary Artery Disease

Saffari et al (2013) studied the effect of the MTHFR C677T on high homocysteine levels and therefore coronary artery disease (CAD). Therefore, the presence of C677T and total homocysteine were studied in a group patients with CAD. While homocystiene levels were found to be higher in the CAD study group, the study did not find an increased prevalence of the MTHFR C677T mutation in the CAD group when compared to controls.

Article Here

4. C677T, A1298C, Hypertension & Hypertension in Pregnancy

Yang et al (2014) wished to uncover the role of both the C677T and A1298C mutation in relation to hypertension (H) and hypertension in pregnancy (HIP). Results showed the C677T mutation was assoicated with both H and HIP in Asain and Caucasian populations, with the A1298C mutation no proving to show links with these disease states.

Article Here

5. Gene Mutations in CVD

Patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) for the presence of 6 different gene polymorphisms relating to CV health, including MTHFR C677T and A1298C mutations. C677T homozygous and heterozygous mutations (TT and CC) were found in 9.34% and 41.09% of patients respectively, with the A1298C homozygous and heterozygous mutations found in 13.78% and 44.94% of patients. Of all screened, no genetic mutation was found in only 1.95% of subjects. This research highlights how vital the screening of genetic mutations for the diagnosis and potential treatment of CVD.

Article Here

 

 

Related Posts

Neuropathy
Conditions

Neuropathy

What is Neuropathy? Neuropathy describes any disease involving the peripheral nerves, usually weakness and numbness. It can either affect a single nerve or many nerves, ...
Read More →
Haddock in Tomato and Basil Sauce
MTHFR

Haddock in Tomato and Basil Sauce

This delicious recipe sourced from the Iodine global network contains 324 mcg of iodine SERVES 4 Ingredients 400g x 1 can tomatoes, canned, whole contents ...
Read More →
How Prebiotics Can Support Gut Health, Metabolic Syndrome and Fertility
MTHFR

How Prebiotics Can Support Gut Health, Metabolic Syndrome and Fertility

In natural medicine, it’s a widely accepted notion that having a healthy gut leads to better health overall. There is growing evidence of the crucial ...
Read More →
Is MTHFR Related to Anaemia?
Genes

Is MTHFR Related to Anaemia?

Anaemia is considered to be one of the most common blood conditions in the world. This condition relates to the abnormal or lack of functioning ...
Read More →
Did You Know? Creatine
MTHFR

Did You Know? Creatine

You may have heard of creatine before, probably for its ability to enhance athletic performance. But, did you know that creatine can also help improve ...
Read More →
Low Homocysteine Levels: What are The Consequences?
MTHFR

Low Homocysteine Levels: What are The Consequences?

Low Homocysteine Levels: What are The Consequences? Homocysteine is an amino acid derivative that serves as an intermediate in the synthesis of methionine and cysteine. ...
Read More →
Scroll to Top
Carolyn Ledowsky

Stay Connected!

Sign up for our monthly newsletter with current MTHFR research, health tips, recipes, special offers and news about upcoming events including Carolyn’s live Q&A.

Subscribe