Studies have suggested MTHFR C677T plays a role in the development of Cardiovascular Disease (CVD) in populations with low dietary folate intake. Therefore, the authors aimed to examine the association between MTHFR, folate and CVD related outcomes in a population with no mandatory folic acid fortification.
Results showed the MTHFR genotype was not associated with hypertension, dyslipidaemia, stroke or all-cause mortality. Those with the MTHFR 677TT genotype were found to have a higher risk of Ischemic Heart Disease.
