Settin et al (2014) researched the link between mutations in the MTHFR genes and the susceptibility for and complications of Type 2 Diabetes Mellitus (T2DM). Results showed those with the 677TT and 1298AA mutations were more susceptible to T2DM. Furthermore, these mutations were also found to be risk factors for

Varicocele is the presence of widened veins, like varicose veins on the outside of the testicle and is one of the main reasons for male infertility. The MTHFR enzyme is also vital for production of healthy DNA, which is needed to create healthy sperm. Therefore, Ucar et al (2014) evaluated

Studies have suggested MTHFR C677T plays a role in the development of Cardiovascular Disease (CVD) in populations with low dietary folate intake. Therefore, the authors aimed to examine the association between MTHFR, folate and CVD related outcomes in a population with no mandatory folic acid fortification. Results showed the MTHFR

The authors Wang et al (2014) studied the ability of MTHFR C677T  to predict high homocysteine in Chinese patients with hypertension. Overall, the 677TT genotype was consistently associated with higher homocysteine across the group, with the increase averaging 51%. The authors conclude that the MTHFR C677T polymorphisms could be used

This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It lists the main functional polymorphisms of the MTHFR gene to be C677T and A1298C. In regards to the C677T mutation, the heterozygous C677T mutation functions at 65% activity, with homozygous

Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms, of which MTHFR mutations C677T and A1298C were included. The C677T mutation was the most common MTHFR genotype presentation by the patients in the study, showing predominance toward increased

The relationship between homocysteine (Hcy), MTHFR C677T polymorphism and cerebral (brain) blood clot risk was studied by Bharatkumar et al (2014). Homocysteine was higher in patients with cerebral blood clotting, representing a 4.54 fold increased risk of brain blood clotting. When examining the link with MTHFR C677T, the authors concluded

Research conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (Liver Cancer) risk in a Chinese Population. Results showed that both the C677T and A1298C mutation were significantly associated with an increased susceptibility to liver cancer. Article Here  

The true cause of blood clotting of the retina’s vein was examined in this study be Mrad et al (2014). Results showed the A1298C polymorphism to be significantly associated with clotting of the retinal vein. The C677T gene was found to be significantly higher among these patients. Article Here  

Zhu et al (2013) examined evidence to uncover an association between MTHFR C677T  and the risk of PD, with overall risk found to be increased in European populations compared with Asian populations. Article Here  

Research conducted by Davis et al (2014) found patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis had a 3.05 increased risk of adverse events in the presence of the A1298C mutation. Article Here