Lee & Song (2014) conducted a meta-analysis to explore whether plasminogen activator inhibitors-1 (PAI-1) 4G/5G and MTHFR C677T polymorphisms are associated with susceptibility to Polycystic Ovarian Syndrome (PCOS). 9 studies examining PAI-1 with 2384 total subject were employed for analysis, along with 8 studies with 1270 total subjects for MTHFR C677T. Meta-analysis of the

This study was completed in order to examine whether the 677TT polymorphism exhibited adaptive developmental plasticity in 1818 South Indian subjects (895 males + 923 females). The frequency of MTHFR 677T was 9.1% in males + 11.0% in females. The 677T allele was highest in the 20-40 years age group, gradually decreasing as

A case control study was undertaken to examine the association between common mTHFR C677T/ A1298C polymorphisms and the Arg72ro polymorphisms in the P53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women. 131 women with a diagnosis of CIN I or II were recruited,

Evidence has recently revealed that patients with vitiligo are shown to have elevated total Homocysteine (Hcy). As MTHFR is one of the main enzymes that regulates HCy metabolism, it is hypothesized by the authors that polymorphisms to these genes could contribute to vitiligo development. 1000 Chinese patients with vitiligo matched with 1000 healthy controls

This meta-analysis was undertaken to review the current evidence available examining the link between the MTHFR C677T polymorphism and migraine risk across numerous populations. 17 studies were used for this review, with a total of 8903 cases and 27, 637 controls. Collective results showed the 677T allele was significantly associated with an increased risk

Ojha and Gurney (2014) conducted a meta-analysis to deduce whether the MTHFR C677T mutation was associated with overall survival in paediatric acute lymphoblastic leukaemia. Six studies were employed, totalling 909 paediatric patients with ALL. The current evidence suggests that individuals with at least one T allele in the C677T gene code may have

Settin et al (2014) researched the link between polymorphisms in both ACE and MTHFR genes and the susceptibility for and complications of Type 2 Diabetes Mellitus (T2DM) in an Eygyptian population. 203 patients with T2DM were studied alongside 311 healthy controls, with ACE and MTHFR C677T and A1298C genotyped. Results showed those with the

The MTHFR enzyme is vital for DNA synthesis and methylation, which has a key role during spermatogenesis. Varicocele is one of the main reasons for male infertility, of which the aetiology remains unclear. Therefore, Ucar et al (2014) evaluated the C677T and A1298C polymorphism frequency in patients with varicocele and normal men, as

Studies have suggested an effect of MTHFR C677T genotype on CVD in populations with low dietary folate intake. Therefore, the authors aimed to examine the association between MTHFR, serum folate B12 and CVD related outcomes in a population with no mandatory folic acid fortification policy. MTHFR C677T, serum folate, serum B12, hypertension and dyslipidaemia

The authors Wang et al (2014) studied the ability of the MTHFR C677T polymorphism to predict hyperhomocysteinemia (HHcy) in Chinese patients with hypertension. Plasma Hcy and the C677T genotype were examined in 1058 Chinese patients with hypertension. No control group appears to have been used. Overall, the 677TT genotype was consistently associated with higher

This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It lists the main functional polymorphisms of the MTHFR gene to be C677T, A1298C, with other reported polymorphisms known for genes T1059C, T1317C and G1793A. In regards to the C677T mutation, the heterozygous C677T mutation

Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms, of which MTHFR mutations C677T and A1298C were included. 372 CRC Korean patients (215 men and 157 women) were genotyped to examine genetic expression. Interestingly, the C677T mutation was the most common MTHFR