Song et al (2013) examined the association between several cancer related genes with the prevalence of MTHFR in patients with gastric cancer. Hypermethylation of these cancer related genes was highly evident, which could therefore be used as predictive biomarkers in the detection of gastric cancer. Patients with MTHFR 677TT mutations

A meta-analysis on the available evidence concerning the MTHFR C677T polymorphism and susceptibility to epilepsy was studied by Wu et al (2014). Ten studies totaling 1713 cases and 1867 controls were examined, with a significant association between the C677T mutation and epilepsy susceptibility demonstrated. When analysing the evidence in relation

A review on the available evidence concerning MTHFR C677T and susceptibility to epilepsy was studied by Wu et al (2014). Ten studies were examined, with an association between the C677T mutation and epilepsy susceptibility was found. When examining the evidence in relation to ethnicity, the results also indicated the MTHFR

This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age and occurrence of late life depression, and whether these mutations predicted the response to antidepressant medication. 304 Caucasians were studied in this research, 198 with depression and 106 without. Intake

This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age and occurrence of late life depression, and whether these mutations predicted the response to antidepressant medication. The main results showed a mutation in the MTRR gene involved in B12 metabolism,

Lochman et al (2014) state a possible epigenetic link between MTHFR C677T mutations, high homocysteine and schizophrenia. 192 schizophrenic patients were examined alongside 213 controls, with an increased risk of schizophrenia presentation associated both MTHFR 677 CT and TT mutations. The authors also studied the relationship between C677T, COMT and

Lochman et al (2014) state a possible link between MTHFR C677T mutations, high homocysteine and schizophrenia. Through examining a group of schizophrenic patients, an increased risk of schizophrenia presentation was associated with MTHFR 677 CT and TT mutations when compared to healthy people. The authors also studied the relationship between

Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that are linked with major depressive disorder (MDD). 86 South African patients diagnosed with MDD were studied alongside 97 controls were examined for an interrelationship between these inter-playing factors of methylation. Results found

Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that have been found to be linked with major depressive disorder (MDD). Patients diagnosed with MDD were screened to find the folate level to be lower in this group when compared to controls.

4709 Turkish patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) over a period of 3 years for the presence of 6 different gene polymorphisms relating to CV health, including Factor 5 Leiden, Prothrombin, Factor 8, MTHFR C677T, A1298C mutations and PAI-1. C677T homozygous and heterozygous mutations

Patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) for the presence of 6 different gene polymorphisms relating to CV health, including MTHFR C677T and A1298C mutations. C677T homozygous and heterozygous mutations (TT and CC) were found in 9.34% and 41.09% of patients respectively, with the A1298C

This review article by Rozycka et al (2014) discusses hyperhomocysteinemia (HHcy) and its effect on Alzheimer’s and Parkinson’s Disease. This is due HHcy being found to have a neurotoxic effect that participates in neuro-degeneration via excititoxicity, oxidative stress calcium accumulation and apoptosis. HHcy has been thought to interact with dopaminergic