Latest Research

As latest research comes to hand, we will post links and summaries here for you to access.

Methylation and HPV/ Cervical Cancer

Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve rates of cervical cancer prevention.  The authors Brandsma et al (2014) previously studied 113 samples of HPV genes and discovered different levels of methylation at different levels of pre-malignancy (cancer

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Methylation, MTHFR and Gastric Cancer

Song et al (2013) examined the association between several cancer related genes with the prevalence of MTHFR in patients with gastric cancer. Hypermethylation of these cancer related genes was highly evident, which could therefore be used as predictive biomarkers in the detection of gastric cancer. Patients with MTHFR 677TT mutations

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MTHFR C677T and Epilepsy

A review on the available evidence concerning MTHFR C677T and susceptibility to epilepsy was studied by Wu et al (2014). Ten studies were examined, with an association between the C677T mutation and epilepsy susceptibility was found. When examining the evidence in relation to ethnicity, the results also indicated the MTHFR

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Folate metabolism and Depression

This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age and occurrence of late life depression, and whether these mutations predicted the response to antidepressant medication. The main results showed a mutation in the MTRR gene involved in B12 metabolism,

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MTHHFR C677T and Schizophrenia

Lochman et al (2014) state a possible link between MTHFR C677T mutations, high homocysteine and schizophrenia. Through examining a group of schizophrenic patients, an increased risk of schizophrenia presentation was associated with MTHFR 677 CT and TT mutations when compared to healthy people. The authors also studied the relationship between

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Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application

Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that are linked with major depressive disorder (MDD). 86 South African patients diagnosed with MDD were studied alongside 97 controls were examined for an interrelationship between these inter-playing factors of methylation. Results found

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Folate, Methylation and Depression

Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that have been found to be linked with major depressive disorder (MDD). Patients diagnosed with MDD were screened to find the folate level to be lower in this group when compared to controls.

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