As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. As the C677T MTHFR mutation is has been well studied in affecting DNA methylation, the authors focused

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the relationship between male infertility and the MTHFR and MTRR polymorphisms. 150 Jordanian men presenting with

Methylation and the folate pathway are expected to play an important role in the production of healtyh sperm as they are involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the relationship between male infertility and the MTHFR and MTRR polymorphisms. Results showed an association between

The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for several disease states such as miscarriage, birth defects and heart disease. While these effects are highly undesirable, the mutation is prevalent in many populations, with the Mediterranean region having one

The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease states. While these are undesirable, the mutation is widespread across many populations worldwide. One of these is the Mediterranean region, which has one of the highest frequencies of the MTHFR

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed with pre-eclampsia (PE) verse 150 control women. Homocysteine (Hcy) levels were also measured in women with the homozygous 1298CC mutation. Of both the genes and their polymorphisms, only women with

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first children diagnosed with pre-eclampsia (PE). Homocysteine (Hcy) levels were also measured in women with the homozygous 1298CC mutation. Of both the genes and their polymorphisms, only women with the 1298CC

Development while in the uterus is recognised as a determinate of health in later life and is known as early life programming. Several human studies have shown a link between in utero stressors such as maternal stress, anxiety and depression with adverse behavioural outcomes for the offspring including poorer cognitive

Development while in the uterus is recognised as a determinate of health in later life and is known as early life programming. Several human studies have shown a link between in utero stressors such as maternal stress, anxiety and depression with adverse behavioural outcomes for the offspring including poorer cognitive

Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as UV light, silica, infections and cigarette smoke. However, it is unknown how this oxidative stress modified the immune system in order to create a Lupus flare up. The authors Li

Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as UV light, silica, infections and cigarette smoke. However, it is unknown how this oxidative stress modified the immune system in order to create a Lupus flare up. The authors Li

African American (EA) women are more likely than European American (EA) women to be diagnosed with breast cancer at a young age and to develop tumours with a poor prognosis, with this racial difference largely unexplained. While nutrients involved in the methylation cycle have been linked with breast cancer, Gong