Zhang et al (2013) have studied the association between several genes involved in folate metabolism and the risk of developing Neural Tube Defects, of which are the most common and severe congenital malformation worldwide. This meta-analysis examined 85 studies focusing on MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G and

Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into 3 groups, and either fed 2mg (the control diet), 5mg (recommended supplemental intake) or 40mg (high intake) of folic acid per kg of diet. All of the male offspring were

Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into 3 groups, and either fed 2mg (the control diet), 5mg (recommended supplemental intake) or 40mg (high intake) of folic acid per kg of diet. All of the male offspring were

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. As the C677T MTHFR mutation is has been well studied in affecting DNA methylation, the authors focused

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. The MTHFR gene is involved in converting folates into the active 5methylfolate, with the MTR gene involved

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the relationship between male infertility and the MTHFR and MTRR polymorphisms. 150 Jordanian men presenting with

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the relationship between male infertility and the MTHFR and MTRR polymorphisms. Results showed an association between

The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for several disease states such as miscarriage, birth defects and heart disease. While these effects are highly undesirable, the mutation is prevalent in many populations, with the Mediterranean region having one

The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease states. While these are undesirable, the mutation is widespread across many populations worldwide. One of these is the Mediterranean region, which has one of the highest frequencies of the MTHFR

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed with pre-eclampsia (PE) verse 150 control women. Homocysteine (Hcy) levels were also measured in women with the homozygous 1298CC mutation. Of both the genes and their polymorphisms, only women with

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first children diagnosed with pre-eclampsia (PE). Homocysteine (Hcy) levels were also measured in women with the homozygous 1298CC mutation. Of both the genes and their polymorphisms, only women with the 1298CC

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation within leukocytes. As the C677T MTHFR mutation is has been well studied in affecting DNA methylation, the