Fatty Liver Disease isn’t Just an Alcohol Issue It turns out that alcohol isn’t the only culprit when it comes to fatty liver disease (FLD). Elevated homocysteine levels are associated with non-alcoholic fatty liver disease (NAFLD), an often silent but serious disease that causes fat in the liver and inflammation

A stroke can be frightening, debilitating, and sometimes deadly. Strokes are complicated events caused by a variety of contributing factors, including genetics and environment. One potential factor is an elevated level of homocysteine in blood plasma. Homocysteine is a chemical created by the breakdown of an amino acid called methionine.

Adult acute myeloid leukemia (AML) is a rapidly progressing cancer of the blood and bone marrow that affects the myeloid type of white blood cells, called myeloblasts. It’s the most common type of acute leukemia in adults. It affects men and smokers more often than other people. Previous chemotherapy recipients

Zhang et al (2013) have studied the association between several genes involved in folate metabolism and the risk of developing Neural Tube Defects, of which are the most common and severe congenital malformation worldwide. This meta-analysis examined 85 studies focusing on MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G and

Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into 3 groups, and either fed 2mg (the control diet), 5mg (recommended supplemental intake) or 40mg (high intake) of folic acid per kg of diet. All of the male offspring were

Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into 3 groups, and either fed 2mg (the control diet), 5mg (recommended supplemental intake) or 40mg (high intake) of folic acid per kg of diet. All of the male offspring were

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. As the C677T MTHFR mutation is has been well studied in affecting DNA methylation, the authors focused

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. The MTHFR gene is involved in converting folates into the active 5methylfolate, with the MTR gene involved

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the relationship between male infertility and the MTHFR and MTRR polymorphisms. 150 Jordanian men presenting with

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the relationship between male infertility and the MTHFR and MTRR polymorphisms. Results showed an association between

The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for several disease states such as miscarriage, birth defects and heart disease. While these effects are highly undesirable, the mutation is prevalent in many populations, with the Mediterranean region having one

The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease states. While these are undesirable, the mutation is widespread across many populations worldwide. One of these is the Mediterranean region, which has one of the highest frequencies of the MTHFR