MTHFR Support

Dr Carrie Jones

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ND, MPH. Medical Director of Precision Analytical.

[/vc_column_text][/vc_column][vc_column width=”3/4″][vc_tta_tabs style=”modern” color=”white” active_section=”1″][vc_tta_section title=”About Speaker” tab_id=”1493848067536-ce786fab-b61e”][vc_column_text]Dr. Carrie Jones’ passion and expertise lies in the areas of hormonal, adrenal, and thyroid health. She recognises that imbalance can occur at any age and believes it is important to look at the big picture such as the appropriate use of lab testing. Dr. Jones graduated from the National University of Natural Medicine (NUNM) in Portland, Oregon then went on to complete her residency in women’s health, endocrinology and hormones. Later she graduated from Grand Canyon University’s Master of Public Health program with a goal of doing more international work and health empowerment. Dr. Jones is an adjunct professor at NUNM and regularly consults, lectures, and writes on the topic of hormones, thyroid, adrenals, autoimmune and more both nationally and internationally. As the Medical Director for Precision Analytical, Inc., her goals are to provide ongoing cutting edge integrative clinical education to the large network of providers paving the way of healthcare with functional medicine.[/vc_column_text][/vc_tta_section][vc_tta_section title=”Speaker Topic” tab_id=”1493848067788-b21528f0-e270″][vc_column_text]

When Hormones, Organic Acids and Genetics Collide: How to put the puzzle pieces of testing together.

Description: Laboratory testing is an important tool in Functional Medicine. Hormones and their metabolites have long been a staple of Functional Medicine practices. Organic acids and genetic testing have more recently emerged as important tools to also be considered, especially in complex cases. These types of lab testing are useful when considered independently but are more powerful when considered in concert with each other as well as the clinical picture. In many cases having more comprehensive testing makes proper diagnosis more likely.  This lecture will discuss the integration of these three testing modalities, especially as it relates to estrogen metabolism and cancer prevention.

The intersections of organic acids and genetic testing with hormones are most plentiful when considering estrogen and its metabolism. This lecture will expand on the testing of estradiol and its phase I and II metabolites. Many common genetic tests relate directly to estrogen metabolism. While genetics can influence the metabolism of estrogen, nutrient deficiencies can also play a role even in the absence of a genetic defect. Many of these nutrient deficiencies increase the levels of specific organic acids and these markers add an additional layer of information. Consideration of all three modalities can be overwhelming without familiarity of the interdependence between these different lab tests; however, clinical accuracy can improve with the synergy of the information available.

While the increased volume of information in these specialty tests can be useful, there is also a risk of missing the most relevant clinical conclusions amidst the noise of markers that may not be relevant for a particular case. This presentation will also help providers filter out clinically important findings from the distractions of results that may be abnormal, yet without as much significance given the entirety of the case.


  1. A brief introduction to Hormones, Organic Acids and Genetic Testing
    1. Assessing hormone levels and metabolism patterns
    2. Organic acids – potential utility with caveats
    3. Genetic testing – finding clinical utility and avoiding irrelevancy
  2. Understanding estrogen metabolism and its clinical relevance
    1. Phase I metabolism and estrogen metabolite ratios
    2. Phase II metabolism
    3. Genetic influences on both phase I and II metabolism
  3. How nutrient deficiencies, revealed by Organic Acid Testing, influence estrogen metabolism
    1. The case for the relevance of organic acids
    2. The limitations of organic acids – avoiding overleveraging markers


This presentation will include a fascinating mix of biochemistry, research studies and case studies to help providers know where hormone, genetic and organic testing can be leveraged clinically in isolation or in combination. Each of the tests discussed have their own complexities and Mark Newman has unique expertise to assist providers in navigating each. Functional Medicine employs many tools seldom utilized in traditional medicine. This presentation will assist providers in navigating complex lab testing to optimize treatment to improve health and decrease risk for, among other things, related cancers.[/vc_column_text][/vc_tta_section][/vc_tta_tabs][/vc_column][/vc_row]

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