MTHFR Support

Spina bifida

What is Spina bifida?

Spina bifida is termed a ‘Neural Tube Defect’ (NTD), and is a developmental defect in which the newborn baby has part of the spinal cord and its coverings exposed through a gap in the backbone.

The symptoms may include paralysis of the legs, incontinence, and leaning disabilities from the commonly associated brain defects.


Yaliwal & Desai (2012) state the C677T  MTHFR gene mutation is associated with a 2-4 fold increased in the risk of developing a NTD if the patient is homozygous (677TT). This risk is modulated by folate levels both ingested and then found within the body . The A1298C mutation is still linked to NTD, but will smaller relative risk.

Article Here




Scroll to Top
Carolyn Ledowsky

Stay Connected!

Sign up for our monthly newsletter with current MTHFR research, health tips, recipes, special offers and news about upcoming events including Carolyn’s live Q&A.