MTHFR Support

Recurrent Miscarriage

What is Recurrent Miscarriage/ Pregnancy Loss?

Recurrent pregnancy loss is a condition distinct from infertility, and is defined as two or more failed pregnancies.

A miscarriage is defined as a baby who dies before 20 weeks gestation and/or has a birth weight of less than 400g. Babies who die after 20 weeks are classified as stillborn.


The DNA of women with a history of Recurrent Pregnancy Loss (RPL) was examined to discover if MTHFR mutations were impacting negatively on pregnancy outcomes. When compared to healthy controls, the T allele of the C677T mutation was found to be associated with RPL. The C677T mutation conferred a 1.63 and the 677TT mutation conferred a 6.3 increased risk of RPL in these study subjects.

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Carolyn Ledowsky

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