
The COMT-Dopamine Connection: Why Your Patient Isn’t Lazy—They’re Biochemically Flatlined
When a patient presents with low motivation, emotional flatness, addictive behaviours, or an inability to complete even simple tasks, it’s easy to mistake them as “non-compliant” or “uncommitted.” But what if the problem isn’t psychological? What if it’s biochemical? In clinical genomics, we now understand that fast COMT activity—driven by genetic variation—can deplete dopamine levels