Category: Genes

What vitamin B6’s active form (PLP) reveals about enzyme fidelity, neurological resilience, and why ‘more B6’ isn’t always the right answer. The B Vitamin We Thought We Understood Ask any clinician to name the functions of vitamin B6, and you’ll hear the usual suspects: amino acid metabolism, neurotransmitter synthesis, perhaps a nod to its role

Kidney stones aren’t just a dietary issue—they’re a microbial one. Here’s how the absence of one bacterial species could reshape how we think about nephrolithiasis. What We Miss When We Only Focus on Oxalate Intake Calcium oxalate stones are the most common type of kidney stone—and if you’ve had one, the recurrence risk is high.

If you think methylation is just about MTHFR and folate, think again. There’s a rare disease that forces us to reckon with the very fundamentals of sulfur metabolism—and it teaches us more than you’d expect about the broader landscape of chronic disease, longevity, and metabolic resilience. Let’s talk about homocystinuria. It’s rare—so rare that most

What if a standard multivitamin could quietly damage your nerves over time? This isn’t a hypothetical — it’s a clinical pattern showing up with surprising regularity. And for years, we’ve largely misunderstood why. Vitamin B6, often taken in the form of pyridoxine, is essential for over 100 enzymatic reactions. It helps synthesize neurotransmitters, regulate methylation,

How Mould Disrupts Biochemistry, Immunity & Detoxification Understanding the systemic impact of mycotoxins in clinical practice Mould-related illness is often misunderstood as a localised respiratory issue, but in reality, mycotoxins disrupt the body at nearly every level. From mitochondrial damage to immune dysregulation and impaired detoxification, their effects are complex, far-reaching, and deeply biochemical. For

How polymorphisms in sulfur and antioxidant pathways may increase mitochondrial stress and taurine demand Introduction Mitochondrial dysfunction is a core feature of many chronic conditions seen in clinical practice—ranging from cardiovascular disease and neurodegeneration to diabetes, chronic fatigue, and neurodevelopmental disorders. At the cellular level, it manifests as impaired ATP production, increased oxidative stress, calcium

As health practitioners, we’re trained to spot the signs of SIBO: bloating, gas, abdominal pain, inconsistent stools, and food sensitivities. And often, we reach for our tried-and-tested protocols — antimicrobial herbs, probiotics, motility agents, and dietary adjustments like low FODMAP. But what happens when your patient’s SIBO keeps returning? When they’ve tried “everything” — and

Neurotransmitters are fundamental to how our patients think, feel, sleep, move, and cope with stress. While most clinicians are familiar with serotonin and dopamine, a deeper understanding of all neurotransmitter classes—and how genetic, nutritional, and inflammatory factors modulate them—is essential for functional and integrative practice. This blog introduces the five main classes of neurotransmitters, how

Key points discussed: How Vitamin B12 is Absorbed, Transported & Utilised What is Transcobalamin II (TCN2) genes The Role of Genetic Variants in B12 Metabolism Signs & Symptoms of TCN2 Polymorphisms Lab Tests Every Functional Health Practitioner Should Use Diseases & Conditions Linked to TCN2 SNPs  

Nutritional Clues in Recurrent Vaginitis During Pregnancy: What Practitioners Need to Know Recurrent vaginitis during pregnancy remains a challenging clinical concern with potential implications for both maternal and fetal health. While the standard approach focuses on microbiological and symptomatic assessment, emerging evidence suggests a pivotal, yet underexplored, dimension: nutrition. A recent study by Çıkım and