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How Gut Bugs and Inflammation Steal Your Tryptophan (and Your Happiness)

You’ve heard the phrase “the gut-brain axis.” But in clinical practice, that connection runs deeper than many practitioners realise—especially when it comes to tryptophan metabolism and its downstream impact on serotonin, mood, and inflammation. Today’s article dives into the mechanism of tryptophan hijacking—how gut bugs, inflammation, and environmental stress redirect this essential amino acid away …

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The COMT-Dopamine Connection: Why Your Patient Isn’t Lazy—They’re Biochemically Flatlined

When a patient presents with low motivation, emotional flatness, addictive behaviours, or an inability to complete even simple tasks, it’s easy to mistake them as “non-compliant” or “uncommitted.” But what if the problem isn’t psychological?   What if it’s biochemical? In clinical genomics, we now understand that fast COMT activity—driven by genetic variation—can deplete dopamine levels …

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The Science of Serotonin: How MAOA, BH4, and Inflammation Hijack Mood

Serotonin has become a household name. It’s often blamed for depression, and targeted by SSRIs. But as any functional practitioner knows, it’s rarely that simple. In truth, serotonin is influenced by a matrix of genetic factors, cofactors, and environmental inputs—and if you don’t understand these, you’ll struggle to get lasting results with your patients. Today, …

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MTHFR and Methylation: A Critical Insight for Health Practitioners

As a health practitioner, you know that optimal biochemical function is fundamental to patient well-being. One of the most critical yet overlooked biochemical pathways is methylation, a process that affects detoxification, DNA repair, immune function, neurotransmitter balance, fertility and cardiovascular health.  Central to the methylation process is the MTHFR (methylenetetrahydrofolate reductase) enzyme, which plays a …

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The Role of MTHFR in Thyroid Conditions

The Role of MTHFR in Thyroid Conditions: A Deep Dive into the Connection

The thyroid gland, a butterfly-shaped organ located at the base of your neck, plays a pivotal role in regulating metabolism, energy production, and overall health. Thyroid dysfunctions, such as hypothyroidism, hyperthyroidism, Hashimoto’s thyroiditis, and Graves’ disease, affect millions worldwide. While many factors contribute to thyroid issues, one genetic component gaining attention is the MTHFR gene. The MTHFR …

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Vitamin D and Thyroid Health: A Connection Practitioners Can’t Ignore

Vitamin D is widely recognised for its role in bone health, but its impact on the immune system and thyroid health is often overlooked. Emerging research highlights the critical connection between vitamin D levels and autoimmune thyroid conditions, such as Hashimoto’s thyroiditis and Graves’ disease. Its importance is further amplified during pregnancy, where adequate vitamin …

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The Genetics of Autoimmune Thyroid Disorders: A Practitioner’s Guide

Autoimmune thyroid disorders, including Hashimoto’s thyroiditis and Graves’ disease, are among the most common autoimmune conditions worldwide. These disorders arise from a combination of genetic predisposition, environmental triggers, and immune dysregulation. While environmental factors like stress, toxins, and diet play a role, understanding the genetic components offers valuable insights for personalized treatment strategies. This guide explores the role …

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A Post-Pregnancy Thyroid Case Study: What Practitioners Need to Know

Postpartum thyroid dysfunction is a common yet under-recognised condition that can significantly impact a new mother’s health. The physiological and hormonal changes of pregnancy and childbirth create a unique set of challenges for the thyroid gland. Understanding the common patterns seen postpartum and their underlying causes is essential for practitioners to provide effective support. In …

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Genetic Susceptibility of Crohn’s Disease: Uncovering the Role of FUT2 and Other Key Factors

Crohn’s disease, a subtype of inflammatory bowel disease (IBD), presents complex challenges for both patients and practitioners. Despite advanced treatment protocols involving anti-inflammatory medications and tailored dietary plans, many individuals, like Lisa—a 35-year-old woman diagnosed with Crohn’s—continue to experience persistent symptoms, such as abdominal pain, diarrhoea, and fatigue. This raises a critical question: could genetics …

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Carolyn Ledowsky

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