Tito

Methylation is a fundamental biochemical process that underpins everything from gene regulation and detoxification to neurotransmitter production and liver health. Most health practitioners are familiar with folate’s role in methylation—particularly in relation to homocysteine metabolism and MTHFR polymorphisms—but what’s less appreciated is the equally essential role of choline. Emerging research, including a 2025 review by

You’ve heard the phrase “the gut-brain axis.” But in clinical practice, that connection runs deeper than many practitioners realise—especially when it comes to tryptophan metabolism and its downstream impact on serotonin, mood, and inflammation. Today’s article dives into the mechanism of tryptophan hijacking—how gut bugs, inflammation, and environmental stress redirect this essential amino acid away

When a patient presents with low motivation, emotional flatness, addictive behaviours, or an inability to complete even simple tasks, it’s easy to mistake them as “non-compliant” or “uncommitted.” But what if the problem isn’t psychological?   What if it’s biochemical? In clinical genomics, we now understand that fast COMT activity—driven by genetic variation—can deplete dopamine levels

As a health practitioner, you know that optimal biochemical function is fundamental to patient well-being. One of the most critical yet overlooked biochemical pathways is methylation, a process that affects detoxification, DNA repair, immune function, neurotransmitter balance, fertility and cardiovascular health.  Central to the methylation process is the MTHFR (methylenetetrahydrofolate reductase) enzyme, which plays a

Imagine if there was a tiny switch in your body that turned things on and off. This switch controlled vital processes like detoxifying harmful substances, producing energy, and even supporting your mood… Well, in a way there is one! This switch is a process called methylation and it relies heavily on an enzyme called MTHFR

The thyroid gland, a butterfly-shaped organ located at the base of your neck, plays a pivotal role in regulating metabolism, energy production, and overall health. Thyroid dysfunctions, such as hypothyroidism, hyperthyroidism, Hashimoto’s thyroiditis, and Graves’ disease, affect millions worldwide. While many factors contribute to thyroid issues, one genetic component gaining attention is the MTHFR gene. The MTHFR

Vitamin D is widely recognised for its role in bone health, but its impact on the immune system and thyroid health is often overlooked. Emerging research highlights the critical connection between vitamin D levels and autoimmune thyroid conditions, such as Hashimoto’s thyroiditis and Graves’ disease. Its importance is further amplified during pregnancy, where adequate vitamin