Polymorphisms of Folate Metabolism-Related Genes and Survival of Patients with Colorectal Cancer in the Korean Population

Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms, of which MTHFR mutations C677T and A1298C were included. 372 CRC Korean patients (215 men and 157 women) were genotyped to examine genetic expression. Interestingly, the C677T mutation was the most common MTHFR genotype presentation by the patients in the study, showing predominance toward increased tumour size and advanced stages of cancer. These findings were not however defined as significant.

It could therefore be hypothesized that a MTHFR polymorphism could potentially have no impact on or decrease survival rates in CRC, via compounding the toxicity of anti-folate drugs commonly used (such as 5-Fluorouracil). This would instead negatively affect overall survival in patients, instead of aiding in overall survival as studied in this research.

February 10, 2014
Save & Share Cart
Your Shopping Cart will be saved and you'll be given a link. You, or anyone with the link, can use it to retrieve your Cart at any time.
Back Save & Share Cart
Your Shopping Cart will be saved with Product pictures and information, and Cart Totals. Then send it to yourself, or a friend, with a link to retrieve it at any time.
Your cart email sent successfully :)