MTHFR/p53 Polymorphisms as Genetic Factors for Cervical Intraepithelial Neoplasia and Cervical Cancer in HPV-infected Mexican Women

A case control study was undertaken to examine the association between common mTHFR C677T/ A1298C polymorphisms and the Arg72ro polymorphisms in the P53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women. 131 women with a diagnosis of CIN I or II were recruited, along with 78 women with CIN III or ICC. These women were compared to 274 women negative for HPV virus and a normal Pap Smear. Result suggested that the A1298C polymorphism contributed to the genetic risk for both CIN and ICC.

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