Methylenetetrahydrofolate Reductase (MTHFR) genetic polymorphisms and the risk of infertility in couples accessing Assisted Reproductive technologies

Objectives

The aim of this literature review is to examine the relationship between Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and assisted reproductive technologies in men and women accessing fertility services.

Design

Systematic literature review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses

Methods

This systematic literature review involved searches conducted through the Medline, EMBASE, CINAHL and Scopus databases to identify observational studies examining MTHFR polymorphism incidence in infertile couples seeking support through In vitro fertilisation and/or Fertility clinics.

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July 1, 2021