The MTHFR enzyme is vital for DNA synthesis and methylation, which has a key role during spermatogenesis. Varicocele is one of the main reasons for male infertility, of which the aetiology remains unclear. Therefore, Ucar et al (2014) evaluated the C677T and A1298C polymorphism frequency in patients with varicocele and normal men, as literature suggests MTHFR polymorphisms may be a risk factor for male infertility. 107 varicocele patients’ vs 109 fertile healthy individuals were included. The presence of the 1298AA allele was found to be significantly higher in the patient group compared to controls, with result showing 1298AA increased the risk of varicocele by approximately 2.3 times when compared to men carrying other genotypes.
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