Gene Mutations in Cardiovascular Disease

Patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) for the presence of 6 different gene polymorphisms relating to CV health, including MTHFR C677T and A1298C mutations. C677T homozygous and heterozygous mutations (TT and CC) were found in 9.34% and 41.09% of patients respectively, with the A1298C homozygous and heterozygous mutations found in 13.78% and 44.94% of patients. Of all screened, no genetic mutation was found in only 1.95% of subjects. This research highlights how vital the screening of genetic mutations for the diagnosis and potential treatment of CVD.

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February 21, 2014
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