PMID- 26500463
OWN – NLM
STAT- MEDLINE
DCOM- 20160329
LR – 20201209
IS – 1550-2783 (Print)
IS – 1550-2783 (Electronic)
IS – 1550-2783 (Linking)
VI – 12
DP – 2015
TI – Effects of zeolite supplementation on parameters of intestinal barrier integrity,
inflammation, redoxbiology and performance in aerobically trained subjects.
PG – 40
LID – 10.1186/s12970-015-0101-z [doi]
LID – 40
AB – BACKGROUND: Zeolites are crystalline compounds with microporous structures of
Si-tetrahedrons. In the gut, these silicates could act as adsorbents,
ion-exchangers, catalysts, detergents or anti-diarrheic agents. This study evaluated
whether zeolite supplementation affects biomarkers of intestinal wall permeability
and parameters of oxidation and inflammation in aerobically trained individuals, and
whether it could improve their performance. METHODS: In a randomized,
double-blinded, placebo controlled trial, 52 endurance trained men and women,
similar in body fat, non-smokers, 20-50 years, received 1.85 g of zeolite per day
for 12 weeks. Stool samples for determination of intestinal wall integrity
biomarkers were collected. From blood, markers of redox biology, inflammation, and
DNA damage were determined at the beginning and the end of the study. In addition,
VO2max and maximum performance were evaluated at baseline and after 12 weeks of
treatment. For statistical analyses a 2-factor ANOVA was used. RESULTS: At baseline
both groups showed slightly increased stool zonulin concentrations above normal.
After 12 weeks with zeolite zonulin was significantly (p < 0.05) decreased in the
supplemented group. IL-10 increased tendentially (p < 0.1) in the zeolite group.
There were no significant changes observed in the other measured parameters.
CONCLUSIONS: Twelve weeks of zeolite supplementation exerted beneficial effects on
intestinal wall integrity as indicated via decreased concentrations of the tight
junction modulator zonulin. This was accompanied by mild anti-inflammatory effects
in this cohort of aerobically trained subjects. Further research is needed to
explore mechanistic explanations for the observations in this study.
FAU – Lamprecht, Manfred
AU – Lamprecht M
AD – Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria ;
Institute of Nutrient Research and Sport Nutrition, Graz, Austria.
FAU – Bogner, Simon
AU – Bogner S
AD – Institute of Nutrient Research and Sport Nutrition, Graz, Austria.
FAU – Steinbauer, Kurt
AU – Steinbauer K
AD – SportchirurgiePlus, Graz, Austria.
FAU – Schuetz, Burkhard
AU – Schuetz B
AD – Biovis Diagnostic MVZ GmbH, Limburg, Germany.
FAU – Greilberger, Joachim F
AU – Greilberger JF
AD – Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria ;
Institute of Laboratory Sciences, Dr Greilberger GmbH, Laßnitzhöhe, Austria.
FAU – Leber, Bettina
AU – Leber B
AD – Department of Surgery, Division of Transplantation Surgery, Medical University of
Graz, Graz, Austria.
FAU – Wagner, Bernhard
AU – Wagner B
AD – FH JOANNEUM Ltd, Graz, Austria.
FAU – Zinser, Erwin
AU – Zinser E
AD – FH JOANNEUM Ltd, Graz, Austria.
FAU – Petek, Thomas
AU – Petek T
AD – Medical and Chemical Laboratory diagnostics Lorenz & Petek Ltd, Graz, Austria.
FAU – Wallner-Liebmann, Sandra
AU – Wallner-Liebmann S
AD – Institute of Pathophysiology and Immunology, Medical University of Graz, Graz,
Austria.
FAU – Oberwinkler, Tanja
AU – Oberwinkler T
AD – Panaceo International Active Mineral Production GmbH, Villach, Austria.
FAU – Bachl, Norbert
AU – Bachl N
AD – Institute of Sport Science, University of Vienna, Vienna, Austria.
FAU – Schippinger, Gert
AU – Schippinger G
AD – SportchirurgiePlus, Graz, Austria.
LA – eng
PT – Journal Article
PT – Randomized Controlled Trial
PT – Research Support, Non-U.S. Gov’t
DEP – 20151020
TA – J Int Soc Sports Nutr
JT – Journal of the International Society of Sports Nutrition
JID – 101234168
RN – 0 (Biomarkers)
RN – 0 (Haptoglobins)
RN – 0 (Interleukin-6)
RN – 0 (Interleukin-8)
RN – 0 (Interleukins)
RN – 0 (Protein Precursors)
RN – 0 (Tumor Necrosis Factor-alpha)
RN – 0 (zonulin)
RN – 130068-27-8 (Interleukin-10)
RN – 1318-02-1 (Zeolites)
RN – 9012-63-9 (Cholera Toxin)
RN – XEO71E2E45 (interleukin-22)
SB – IM
MH – Adult
MH – Biomarkers/blood
MH – Cholera Toxin/metabolism
MH – DNA Damage
MH – *Dietary Supplements
MH – Double-Blind Method
MH – Feces/chemistry
MH – Female
MH – Haptoglobins
MH – Humans
MH – Inflammation/blood/*drug therapy
MH – Interleukin-10/blood
MH – Interleukin-6/blood
MH – Interleukin-8/blood
MH – Interleukins/blood
MH – Intestines/*drug effects
MH – Male
MH – Middle Aged
MH – Nutrition Assessment
MH – Oxygen Consumption
MH – Permeability
MH – Protein Precursors
MH – Tight Junctions/drug effects
MH – Tumor Necrosis Factor-alpha/blood
MH – Zeolites/*pharmacology
PMC – PMC4617723
OTO – NOTNLM
OT – Leaky gut
OT – Tight junctions
OT – Trained subjects
OT – Zeolite supplementation
OT – Zonulin
EDAT- 2015/10/27 06:00
MHDA- 2016/03/30 06:00
CRDT- 2015/10/27 06:00
PHST- 2015/03/09 00:00 [received]
PHST- 2015/10/13 00:00 [accepted]
PHST- 2015/10/27 06:00 [entrez]
PHST- 2015/10/27 06:00 [pubmed]
PHST- 2016/03/30 06:00 [medline]
AID – 101 [pii]
AID – 10.1186/s12970-015-0101-z [doi]
PST – epublish
SO – J Int Soc Sports Nutr. 2015 Oct 20;12:40. doi: 10.1186/s12970-015-0101-z.
eCollection 2015.
Source: PubMed
