A meta-analysis conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (HCC) risk in a Chinese Population, as studies linking the two are currently inconclusive. 12 case controlled studies were included in the analysis, totally 7 studied with 6384 subject examining the MTHFR C677T polymorphism, and five studied with 4502 examining the A1298C polymorphism. Results showed that both the C677T and A1298C mutation were significantly associated with a susceptibility to HCC.
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