Saffari et al (2013) examined the MTHFR C677T mutation and its potential affect on hyperhomocysteinemia (HHcy) and coronary artery disease (CAD). Therefore, the presence of this specific polymorphism and total homocysteine were studied in a group of 457 Iranian patients with multi vessel CAD, and were compared against 371 controls with less than 30% stenosis of all major vessels. However, the presentation of the C677T mutation was not not found to be significantly increased in the CAD group when compared to controls. Plasma homocysteine levels were found to be higher in the CAD study group, and were predicted by smoking habits, folate levels and the presence of a C677T mutation. While the C677T mutation was not specifically linked with CAD in this study, the negative effects of HHcy on cardiovascular health are widely known and well documented.