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Folic Acid SNP’s Associated with Methotrexate Significant Adverse Events in United States Veterans with Rheumatoid Arthritis

319 patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis were genotyped for several SNP’s involved in the folic acid pathway (folylpoly-gamma-glutamate synthetase (FPGS), gamma-glutamyl hydrolase (GGH),MTHFR A1298C + C677T)) to establish their association with MTX + significant adverse events. The results demonstrated the dosing of MTX in the presence of the A1298C mutation was associated with a 3.05 increased risk of adverse events, with the study concluding these SNPs may indicate a susceptibility to MTX toxicity. Information pertaining to the study’s location, presence of a control group, ethnicity studied + mean age/ gender distribution was not available via the abstract, leading to gaps in the understanding + analysis of this research.

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Carolyn Ledowsky

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