Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve rates of cervical cancer prevention. The authors Brandsma et al (2014) previously studied 113 samples of HPV genes and discovered different levels of methylation at different levels of pre-malignancy (cancer growth). Studying samples of cervical cells with both pre-cancer and cancerous presentations found a great trend for increased methylation with increased severity of cancer tissue. Overall, the results supported the potential of using methylation levels of HPV type 16 cells as a predictive biomarker of disease severity.
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