MTHHFR C677T and Schizophrenia

Lochman et al (2014) state a possible link between MTHFR C677T mutations, high homocysteine and schizophrenia. Through examining a group of schizophrenic patients, an increased risk of schizophrenia presentation was associated with MTHFR 677 CT and TT mutations when compared to healthy people. The authors also studied the relationship between C677T mutations and other polymorphisms associated with schizophrenia, and found a link with the ADRA2A polymorphism which governs the release of neurotransmitters (brain chemicals) from nerves within the brain. This study shows there could be malfunctioning occurring a genetic level with both the nervous system and methylation cycle, which is increasing the risk of schizophrenic development.

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