Patients with vitiligo are shown to have elevated Homocysteine (Hcy). As MTHFR is one of the main enzymes that regulates Hcy metabolism, it is hypothesized by authors Chen et al (2014) that mutations to these genes could contribute to vitiligo development.
Vitiligo patients showed lower concentrations of MTHFR and therefore higher levels of Hcy when compared for controls.
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