Settin et al (2014) researched the link between polymorphisms in both ACE and MTHFR genes and the susceptibility for and complications of Type 2 Diabetes Mellitus (T2DM) in an Eygyptian population. 203 patients with T2DM were studied alongside 311 healthy controls, with ACE and MTHFR C677T and A1298C genotyped. Results showed those with the 677TT, 1298AA and ACE (ID + II) mutations were more susceptible to T2DM. MTHFR 677TT allele was a risk factor for diabetic retinopathy, diabetic polyneuropathy and ischemic heart disease, while the 1298CC and AC alleles were a risk factor for diabetic neuropathy. A distinct correlation between MTHFR C677T and A1298C genotypes was demonstrated in this study, in relation to an Egyptian population.