4709 Turkish patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) over a period of 3 years for the presence of 6 different gene polymorphisms relating to CV health, including Factor 5 Leiden, Prothrombin, Factor 8, MTHFR C677T, A1298C mutations and PAI-1. C677T homozygous and heterozygous mutations

Patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) for the presence of 6 different gene polymorphisms relating to CV health, including MTHFR C677T and A1298C mutations. C677T homozygous and heterozygous mutations (TT and CC) were found in 9.34% and 41.09% of patients respectively, with the A1298C

This review article by Rozycka et al (2014) discusses hyperhomocysteinemia (HHcy) and its effect on Alzheimer’s and Parkinson’s Disease. This is due HHcy being found to have a neurotoxic effect that participates in neuro-degeneration via excititoxicity, oxidative stress calcium accumulation and apoptosis. HHcy has been thought to interact with dopaminergic

This review article by Rozycka et al (2014) discusses the harmful effects elevated homocysteine (Hcy) levels can play on diseases affecting brain function such as Alzheimer’s and Parkinson’s Disease. This is due to evidence demonstrating High Hcy to have a toxic effect upon the brain, contributing to degeneration of brain

This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on the treatment of gastric or oesophageal cancer. These mutations can impact upon cancer outcomes as certain chemotherapeutic drugs (e.g. 5-flourouracil) also directly impact the folate pathway, with mutations found here

This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on the treatment of gastric or oesophageal cancer due to their influence on folate metabolism and the drugs that impact upon it e.g. 5-flourouracil. 569 patients with either oesophageal or gastric

High homocysteine in vegetarians and vegans is mainly related to a deficiency in B12. Therefore, methylation in these people can be under-active, but not specifically due to a mutation in an MTHFR gene. This was reflected in a study completed on a vegan and vegetarian population that w Article Here

Hyperhomocysteinemia (HHcy) in vegetarians and vegans is mainly related to a deficiency in B12. However, a mutation in the MTHFR C677T gene may also contribute to HHcy. Therefore, blood status of Hcy, B12, folate, B6 and MTHFR C677T was studied in 109 Thai vegans and 86 omnivores. Vegans were found

The presence of the MTHFR C677T mutation was studied in a group of mothers with Down’s Syndrome children. Results found the 677TT genotype to be present in 1.8% of the case group, with none of the women in the control group found to be carrying this genotype.  The frequency of

The presence of the MTHFR C677T polymorphism was studied by Kaur (2013) in 110 mothers of children with Down’s Syndrome against 111 controls in India. Results from this present study had the 677TT genotype to be present in 1.8% of the case group, whilst none of the control group carried.

Saffari et al (2013) studied the effect of the MTHFR C677T on high homocysteine levels and therefore coronary artery disease (CAD). Overall the correlation between C677T and CAD was not found to be significant, although homocystiene levels were found to be higher in the CAD study group. MTHFR C677T mutation,

Saffari et al (2013) examined the MTHFR C677T mutation and its potential affect on hyperhomocysteinemia (HHcy) and coronary artery disease (CAD). Therefore, the presence of this specific polymorphism and total homocysteine were studied in a group of 457 Iranian patients with multi vessel CAD, and were compared against 371 controls