This study of 4395 children and adolsecents found that exposure to phenols and parabens (endocrine disrupting chemicals) had an impact on folate levels in serum and red blood cells. If RBC folate was optimal bisphenol A, Triclosan, methyl paraben, propyl paraben was better excreted in the urine. And a decrease
New Research of 378,082 people suggests that low serum Vitamin D status is associated with the risk of venous thromboembolism. The VDR gene polymorphisms were measured for each of the participants as this affects levels of Vitamin D. The association was increased amongst people with diabetes regardless of genetic risks
X Fang, S Lee, S Rayalam, HJ Park – Nutrition research (New York, NY) Perinatal stage represents a critical period for brain development. Docosahexaenoic acid (DHA) is a ω-3 polyunsaturated fatty acid preferentially accumulated in the brain that may benefit neurodevelopment. Microbial colonization and maturation parallel … Read more
New research highlights disturbances in methylation with autism spectrum disorder. This study investigated the disturbance of the one carbon metabolism cycle (methylation cycle) with autism spectrum disorder and found that children with Ask had significant differences in SAM, oxidised glutathione, choline, glycine, serine, cystathionine, cysteine and taurine levels. They concluded that understanding
New Research measured the association between MTHFR polymorphisms , MTRR A66G gene polymorphisms with high homocysteine and found that in those that had high homocysteine, taking Vitamin B12 and folate significantly reduced serum homocysteine levels and took away the impact of the genes. Its an interesting study as we have
A recent research study investigating MTHFR polymorphisms and vitamin B12 deficiency found a statistically significant correlation between patients carrying MTHFR C677T homozygous and heterozygous variance and lower haemoglobin value and lower platelet count. And the MTHFR A1298C homozygous and heterozygous variance and lower haemoglobin. Among patients with homozygous for MTHFR
The GSTM1 (Glutathione S-transferase M1) gene plays a crucial role in detoxifying harmful substances and managing oxidative stress in the body, playing a key role in oestrogen metabolism. Deletions of this gene, known as the GSTM1-null genotype, have been linked to an increased risk of ovarian endometriosis and endometriosis-related infertility.
Recurrent pregnancy loss (RPL) is a devastating problem for married couples trying to establish a family, and this problem often presents a perplexing and frustrating challenge for clinicians. RPL is usually defined as three or more consecutive pregnancy losses before a gestational age of 20 weeks; however, this condition has
There is growing evidence that folate status and variation in folate-metabolizing genes are involved in female reproductive functions. This study evaluated the influence of maternal blood folate, vitamin B12, homocysteine and 10 folate pathway gene variants on IVF outcome. Also, the prevalence of these polymorphisms was compared in 439 female
Researchers in the US have just published a paper that shows the higher the urinary phthalate titration the lower the folate in children. This is alarming given that phthalates are all through our environment. We are exposed to phthalates through food, inhalation and skin absorption. Recent evidence also suggests that
This is no revelation however it reinforces how important a healthy diet is in preconception. This study showed that the more ultra processed food women have the higher the homocysteine level. What is interesting is the model of methylation disturbance and gut issues due to an excessive ultra processed food
Background Over 48.5 million couples are reported with infertility worldwide. Health policy recommends folic acid in women of childbearing age, particularly in preconception and pregnancy which results in women purchasing over-the-counter prenatal multivitamins containing folic acid through pharmacies and other retail outlets. Emerging studies are investigating whether other forms of
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