New Research measured the association between MTHFR polymorphisms , MTRR A66G gene polymorphisms with high homocysteine and found that in those that had high homocysteine, taking Vitamin B12 and folate significantly reduced serum homocysteine levels and took away the impact of the genes. Its an interesting study as we have

The GSTM1 (Glutathione S-transferase M1) gene plays a crucial role in detoxifying harmful substances and managing oxidative stress in the body, playing a key role in oestrogen metabolism. Deletions of this gene, known as the GSTM1-null genotype, have been linked to an increased risk of ovarian endometriosis and endometriosis-related infertility.

Recurrent pregnancy loss (RPL) is a devastating problem for married couples trying to establish a family, and this problem often presents a perplexing and frustrating challenge for clinicians. RPL is usually defined as three or more consecutive pregnancy losses before a gestational age of 20 weeks; however, this condition has

There is growing evidence that folate status and variation in folate-metabolizing genes are involved in female reproductive functions. This study evaluated the influence of maternal blood folate, vitamin B12, homocysteine and 10 folate pathway gene variants on IVF outcome. Also, the prevalence of these polymorphisms was compared in 439 female

This is no revelation however it reinforces how important a healthy diet is in preconception. This study showed that the more ultra processed food women have the higher the homocysteine level. What is interesting is the model of methylation disturbance and gut issues due to an excessive ultra processed food

A paper published recently has shown that fathers preconception smoking is associated with a decrease in DNA methylation in the offspring. This was associated with asthma in the offspring. This is consistent with research that suggests that disturbances in the epigenome through parental exposures even before the child is conceived

A newly published 2024 study concludes that long-term supplemental dose of FA leads to prolongation of Oestrous cycle of Sprague Dawley rats. The study showed that continuous use of folic acid @1mg per day disrupted sex hormones including Luteinising hormone (LH) and Follicle stimulating hormone (FSH) which leads to higher

A brand New 2024 study shows that MTHFR C677T is linked to egg quality. This study out of Iraq looked at the MTHFR C677T polymorphism and its affect on IVF procedures ICSI (intracytoplasmic sperm injection). It included 85 infertile women undergoing ICSI treatment, where they tested oocytes (egg), total embryos,