Make sure you’ve read our article on MTHFR so you’ll have a little background on this mutation. What is Methylation? Methylation is the process where a carbon and three hydrogen atoms (aka a methyl group) attach itself to an enzyme in your body. When the methyl group is attached to an enzyme, the said enzyme performs a
Histamine Histamine is a hydrophilic vasoactive amine derived from histidine through carboxylation by L-histidine decarboxylase1. Histamine, once formed, can be stored or rapidly undergo deamination or demethylation, which is catalyzed by diamine oxidase (DAO) or histamine-N-methyltransferase (HNMT) respectively. IgE antibodies on immune cells cause them to degranulate, releasing specific alkaloids and amines capable of displacing
Vitamin B12 is essential to human health. However, some people have inherited conditions that leave them unable to process vitamin B12. As a result they are prone to serious health problems, including developmental delay, psychosis, stroke and dementia. Genes and B12 Deficiency An international research team recently discovered a new genetic disease related to vitamin
Hydroxocobalamin is a precursor to methylcobalamin and Vitamin B12. It is usually prescribed in conditions where B12 cannot be properly absorbed in the gut. It is manufactured naturally as a therapeutic agent with the help of your gut bacteria.1 Hydroxocobalamin is red in color and plays an integral part in DNA replication and synthesis, proper
Methylcobalamin, also referred to as MeB12 and MeCbl, is a member of the cobalamin family and is one of the naturally occurring coenzyme forms of cobalamin found in the human body. Structurally, Methylcobalamin exists in octahedral form with Cobalt (III) at the center containing metal alkyl bonds[1]. It is considered an equivalent to cobalamin and
We already know that vitamin B12, or cobalamin, is an essential nutrient for pregnancy, because it is important for cell growth and baby development. Specifically, B12 works together with folate for the syntheses of DNA, RNA, lipids and proteins inside the cells. Most importantly, B12 and folate are both critical in homocysteine metabolism, DNA methylation,
There is no question that the future of medicine will be in analysing a person’s genetics, with a detailed family history and addressing the genetic inefficiencies of that person. As naturopaths, we will be required to understand more of the mechanisms that drive a person to ill health. Yes, the environment is key, however, there
You know I get really annoyed about the misinformation being spread to people surrounding the MTHFR gene in preconception and pregnancy. I can’t tell you how often I hear people giving advice online and I think “No don’t listen to that! It’s rubbish”. I totally understand that many doctors and practitioners just don’t have the
Should Children with MTHFR Deficiency Receive Scheduled Vaccinations? The Australian government and its public health organization announces that under the changes to the Public Health Act 2010, child care facilities cannot enrol a child unless approved documentation has been provided that shows the child is fully vaccinated for their age.1 Furthermore, the federal president, Dr.
As a statement made by one of the leaders in vitamin B12 field more than 10 years ago, Carmel’s idea of “cobalamin deficiency should not be diagnosed unless megaloblastic changes are found’ is still followed by many physicians and health authorities when accepting B12 deficiency diagnosis.1 But as time goes by, evidence and clinical cases
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